Kojic acid biosynthesis in Aspergillus oryzae is regulated by a Zn(II) sub(2Cys) sub(6) transcriptional activator and induced by kojic acid at the transcriptional level

A gene encoding the Zn(II) sub(2Cys) sub(6) transcriptional factor is clustered with two genes involved in biosynthesis of a secondary metabolite, kojic acid (KA), in Aspergillus oryzae. We determined that the gene was essential for KA production and the transcriptional activation of KA biosynthetic...

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Bibliographic Details
Published in:Journal of bioscience and bioengineering 2011-07, Vol.112 (1), p.40-43
Main Authors: Marui, Junichiro, Yamane, Noriko, Ohashi-Kunihiro, Sumiko, Ando, Tomohiro, Terabayashi, Yasunobu, Sano, Motoaki, Ohashi, Shinichi, Ohshima, Eiji, Tachibana, Kuniharu, Higa, Yoshitaka, Nishimura, Marie, Koike, Hideaki, Machida, Masayuki
Format: Article
Language:English
Subjects:
Aspergillus oryzae
Kojic acid
Secondary metabolites
Transcription activation
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Summary:A gene encoding the Zn(II) sub(2Cys) sub(6) transcriptional factor is clustered with two genes involved in biosynthesis of a secondary metabolite, kojic acid (KA), in Aspergillus oryzae. We determined that the gene was essential for KA production and the transcriptional activation of KA biosynthetic genes, which were triggered by the addition of KA.
ISSN:1389-1723
DOI:10.1016/j.jbiosc.2011.03.010