Post-injury treatment with lipopolysaccharide or lipooligosaccharide protects rat neuronal and glial cell cultures

Highlights ► In vitro scratch of C6 glioma and primary neuronal cells used to model TBI ► Treatment with lipopolysaccharide (LPS) and lipooligosaccharide (LOS) studied ► LPS and LOS treatment post-injury reduced death of C6 cells ► LPS treatment reduced death of primary neuronal cells ► IL-10 was up...

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Bibliographic Details
Published in:Brain research bulletin 2011-07, Vol.85 (6), p.403-409
Main Authors: Bingham, Deborah, John, Constance M, Panter, S. Scott, Jarvis, Gary A
Format: Article
Language:English
Subjects:
Animals
Brain Injuries - immunology
Brain Injuries - physiopathology
Cells, Cultured
Cytokines - metabolism
Escherichia coli
Inflammation
Interleukin-1alpha - metabolism
Interleukin-1beta - metabolism
Interleukin-6 - metabolism
Lipopolysaccharides - pharmacology
LPS
Neisseria meningitidis
Neuroglia - drug effects
Neuroglia - immunology
Neuroglia - pathology
Neurology
Neurons - drug effects
Neurons - immunology
Neurons - pathology
Neuroprotection
Neuroprotective Agents - pharmacology
Rats
Rats, Wistar
Traumatic brain injury
Tumor Necrosis Factor-alpha - metabolism
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Summary:Highlights ► In vitro scratch of C6 glioma and primary neuronal cells used to model TBI ► Treatment with lipopolysaccharide (LPS) and lipooligosaccharide (LOS) studied ► LPS and LOS treatment post-injury reduced death of C6 cells ► LPS treatment reduced death of primary neuronal cells ► IL-10 was upregulated in primary neuronal cells by LPS treatment
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2011.04.007