Management of recurrent Cushing’s disease

Abstract The management of patients with Cushing’s disease remains a major challenge. The remission rate for initial transsphenoidal surgery is reported as 69–94% while the recurrence rate following initially successful transsphenoidal surgery is 2–27%. Treatment options for Cushing’s disease after...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2011-01, Vol.18 (1), p.7-12
Main Authors: Liubinas, Simon V, Porto, Lana Del, Kaye, Andrew H
Format: Article
Language:English
Subjects:
Adenoma - diagnosis
Adenoma - therapy
Cushing Syndrome - diagnosis
Cushing Syndrome - therapy
Cushing’s disease
Female
Humans
Hypophysectomy
Male
Neurology
Outcomes
Pituitary ACTH Hypersecretion - diagnosis
Pituitary ACTH Hypersecretion - therapy
Pituitary adenoma
Pituitary Neoplasms - diagnosis
Pituitary Neoplasms - therapy
Recurrence
Transsphenoidal surgery
Treatment Outcome
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Description
Summary:Abstract The management of patients with Cushing’s disease remains a major challenge. The remission rate for initial transsphenoidal surgery is reported as 69–94% while the recurrence rate following initially successful transsphenoidal surgery is 2–27%. Treatment options for Cushing’s disease after failed initial therapy or recurrence include repeat transsphenoidal surgery, radiotherapy, medical therapy and bilateral adrenalectomy. Management options following unsuccessful initial surgery or recurrence are presented and discussed.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2010.05.001