Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomes

• Published in: Journal of clinical neuroscience 2011-01, Vol.18 (1), p.29-33
• Main Authors: Yang, Isaac, Chang, Edward F, Han, Seunggu J, Barry, Jeffrey J, Fang, Shanna, Tihan, Tarik, Barbaro, Nicholas M, Parsa, Andrew T
• Format: Article
• Language: English
• Subjects: Adult; Adults; Brain Neoplasms - complications; Brain Neoplasms - surgery; Female; Ganglioglioma; Ganglioglioma - complications; Ganglioglioma - surgery; Humans; Male; Neurology; Seizure outcome; Seizures - etiology; Seizures - surgery; Sex Factors; Surgical intervention; Timing of treatment; Treatment Outcome
• ISSN: 0967-5868; 1532-2653
• DOI: 10.1016/j.jocn.2010.05.002

Abstract Gangliogliomas are rare central nervous system tumors, most commonly affecting children and young adults. Chronic seizure and epilepsy are the most frequent presentation of patients with gangliogliomas. In this report, we review the modern literature regarding the effects of early surgical intervention on the clinical outcome of patients with ganglioglioma. A boolean search of PubMed using key words “ganglioglioma”, “adult”, “seizure control”, “treatment”, “surgical intervention”, and “observation”, alone and in combination was performed. The inclusion criteria for articles were that: (i) clinical outcomes were reported specifically for gangliogliomas; (ii) data were reported for adult patients older than the age of 18 years; (iii) treatment data were included for the treatment of gangliogliomas; and (iv) ganglioglioma was the only pathological diagnosis for the evaluation of the tumor. Data were analyzed as a whole then stratified into two groups: early and late treatment intervention. The query identified a total of 99 articles including 1,089 cases of ganglioglioma meeting our inclusion and exclusion criteria. There was a 55% prevalence of males, representing a statistically significant predilection (51–59%, 95% confidence interval). Seizure control was significantly improved when surgical intervention occurred less than 3 years after symptom onset (78% versus 48%; p = 0.0001). Ganglioglioma in adults represents a rare group of tumors, and our systematic analysis suggests a higher prevalence in males. Our findings also support that an early surgical intervention is significantly associated with improved clinical seizure control.