Childhood cow's milk allergy and the risk of multiple sclerosis: A population based study

Abstract Autoimmune mechanisms are thought to have a major role in the pathogenesis of multiple sclerosis (MS) and vitamin D is hypothesised to contribute to disease susceptibility. Cow's milk allergy (CMA) is a common childhood allergy arising from an immune system imbalance and can also lead...

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Bibliographic Details
Published in:Journal of the neurological sciences 2010-04, Vol.291 (1), p.86-88
Main Authors: Ramagopalan, Sreeram V, Dyment, David A, Guimond, Colleen, Orton, Sarah-Michelle, Yee, Irene M, Ebers, George C, Sadovnick, A. Dessa
Format: Article
Language:English
Subjects:
Age of Onset
Autoimmune disease
Biological and medical sciences
Canada
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Epidemiology
F Factor
Female
Humans
Logistic Models
Longitudinal Studies
Male
Medical sciences
Milk allergy
Milk Hypersensitivity - epidemiology
Multiple sclerosis
Multiple Sclerosis - epidemiology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Risk Factors
Spouses
Vitamin D
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Summary:Abstract Autoimmune mechanisms are thought to have a major role in the pathogenesis of multiple sclerosis (MS) and vitamin D is hypothesised to contribute to disease susceptibility. Cow's milk allergy (CMA) is a common childhood allergy arising from an immune system imbalance and can also lead to vitamin D deficiency due to dairy food avoidance. Here, we investigated whether or not CMA influences the subsequent risk to develop MS in a population-based cohort. We identified 6638 MS index cases and 2509 spousal controls with CMA information from the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). Frequency of CMA was compared between index cases and controls. No significant differences were found. Childhood CMA thus does not appear to be a risk factor for MS.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2009.10.021