Three‐dimensional MR‐encephalography: Fast volumetric brain imaging using rosette trajectories

MR‐Encephalography (MREG) is a technique that allows real time observation of functional changes in the brain that appears within 100 msec. The high sampling rate is achieved at the cost of some spatial resolution. The article describes a novel imaging method for fast three‐dimensional‐MR‐encephalog...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2011-05, Vol.65 (5), p.1260-1268
Main Authors: Zahneisen, Benjamin, Grotz, Thimo, Lee, Kuan J., Ohlendorf, Sabine, Reisert, Marco, Zaitsev, Maxim, Hennig, Jürgen
Format: Article
Language:English
Subjects:
Algorithms
Blood
Brain
Brain - physiology
Brain Mapping - methods
Cortex (visual)
Data processing
fast functional imaging
FMRI
Fourier Analysis
Functional magnetic resonance imaging
Hemodynamics
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Magnetic Resonance Imaging - methods
MREG
N.M.R
Neuroimaging
Rosette
Sampling
spatial discrimination
Transformation
volume imaging
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Summary:MR‐Encephalography (MREG) is a technique that allows real time observation of functional changes in the brain that appears within 100 msec. The high sampling rate is achieved at the cost of some spatial resolution. The article describes a novel imaging method for fast three‐dimensional‐MR‐encephalography whole brain coverage based on rosette trajectories and the use of multiple small receiver coils. The technique allows the observation of changes in brain physiology at very high temporal resolution. A highly undersampled three‐dimensional rosette trajectory is chosen, to perform single shot acquisition of k‐space data within 23 msec. By using a 32‐channel head coil array and regularized nonuniform Fourier transformation reconstruction, the spatial resolution is sufficient to detect even subtle centers of activation (e.g. human MT+). The method was applied to visual block design paradigms and compared with echo planar imaging‐based functional MRI. As a proof‐of‐principle of the method's ability to detect local differences in the hemodynamic response functions, the analyzed MR‐encephalography data revealed a spatially dependent delay of the arrival of the blood oxygenation level dependent response within the visual cortex. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
1522-2594
DOI:10.1002/mrm.22711