Simultaneous voltammetric determination for DA, AA and NO2― based on graphene/poly-cyclodextrin/MWCNTs nanocomposite platform

In the present work, graphene sheets (GS) and multiwall carbon nanotubes (MWCNTs) were dispersed in the mixed solution of cyclodextrin (CD) and cyclodextrin prepolymer (pre-CD) and were used as modifier to fabricate chemical modified electrode to simultaneous detect dopamine (DA), ascorbic acid (AA)...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2011-05, Vol.26 (9), p.3977-3980
Main Authors: Zhang, Yu, Yuan, Ruo, Chai, Yaqin, Li, Wenjuan, Zhong, Xia, Zhong, Huaan
Format: Article
Language:English
Subjects:
Ascorbic Acid - chemistry
Ascorbic Acid - isolation & purification
Biological and medical sciences
Biosensing Techniques
Biotechnology
Dopamine - chemistry
Dopamine - isolation & purification
Electrochemistry
Fundamental and applied biological sciences. Psychology
Graphite - chemistry
Microscopy, Electron, Scanning
Nanocomposites - chemistry
Nanotubes, Carbon - chemistry
Nitrites - chemistry
Nitrites - isolation & purification
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Summary:In the present work, graphene sheets (GS) and multiwall carbon nanotubes (MWCNTs) were dispersed in the mixed solution of cyclodextrin (CD) and cyclodextrin prepolymer (pre-CD) and were used as modifier to fabricate chemical modified electrode to simultaneous detect dopamine (DA), ascorbic acid (AA) and nitrite (NO2(-)). CD cross-linked pre-CD (CDP) displays excellent film forming ability, which made the electrode stable. Comparing with CDP-GS, CDP-MWCNTs and CDP-GS-MWCNTs modified electrodes, the CDP-GS-MWCNTs displays higher catalytic activity and selectivity toward the oxidation of DA, AA and NO2(-), revealing that MWCNTs effectively inhibited the stacking of individual GS and enhanced the utilization of GS based composites. The host-guest chemical reaction ability of CD and π-π stacking interaction between detected molecules and GS-MWCNTs surface were considered as the main reasons of the successfully simultaneous detection of DA, AA and NO2(-). Cyclic voltammetry (CV), scanning electron microscopy (SEM) and different pulse voltammetry (DPV) were employed to characterize the biosensor. The linear response range for AA, DA and NO2(-) were 5 μM-0.48 mM, 0.15-21.65 μM and 5 μM-6.75 mM, respectively and the detection limits were 1.65 μM, 0.05 μM and 1.65 μM.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2011.03.017