Childhood methylphenidate treatment of ADHD and response to affective stimuli

Abstract Neural correlates of emotional dysregulation in attention-deficit/hyperactivity disorder (ADHD) and persisting influence of Methylphenidate (MPH) still remain insufficiently understood. Decreased activation in the subgenual cingulate and the ventral striatum were found during the perception...

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Published in:European neuropsychopharmacology 2011-08, Vol.21 (8), p.646-654
Main Authors: Schlochtermeier, Lorna, Stoy, Meline, Schlagenhauf, Florian, Wrase, Jana, Park, Soyoung Q, Friedel, Eva, Huss, Michael, Lehmkuhl, Ulrike, Heinz, Andreas, Ströhle, Andreas
Format: Article
Language:English
Subjects:
Adult
Attention Deficit Disorder with Hyperactivity - drug therapy
Attention Deficit Disorder with Hyperactivity - physiopathology
Attention Deficit Disorder with Hyperactivity - psychology
Attention-deficit/hyperactivity disorder (ADHD)
Basal Ganglia - physiopathology
Child
Emotional pictures
Emotions - drug effects
Emotions - physiology
FMRI
Gyrus Cinguli - physiopathology
Humans
Internal Medicine
Magnetic Resonance Imaging
Male
Methylphenidate
Methylphenidate - therapeutic use
Psychiatric Status Rating Scales
Psychiatry
Subgenual cingulate
Ventral striatum
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Summary:Abstract Neural correlates of emotional dysregulation in attention-deficit/hyperactivity disorder (ADHD) and persisting influence of Methylphenidate (MPH) still remain insufficiently understood. Decreased activation in the subgenual cingulate and the ventral striatum were found during the perception of positive and negative affective pictures in drug-naïve males with ADHD during childhood ( n = 10). Males with ADHD during childhood treated with MPH ( n = 10) did not show any significant differences compared to healthy controls ( n = 10). Further prospective studies need to clarify direct and indirect mechanisms of MPH treatment that may contribute to emotional processing, which is dysfunctional in males without pharmacological treatment in childhood.
ISSN:0924-977X
1873-7862
DOI:10.1016/j.euroneuro.2010.05.001