Mucosal immunosuppression and epithelial barrier defects are key events in murine psychosocial stress-induced colitis

Highlights ► 10 h of psychosocial stress cause local colonic immunosuppression mediated by adrenal hormones. ► 10 h of psychosocial stress result in a reduction of colonic barrier functions. ► 10 h of psychosocial stress cause proliferation and translocation of commensal bacteria. ► Translocation of...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2011-08, Vol.25 (6), p.1153-1161
Main Authors: Reber, Stefan O, Peters, Sebastian, Slattery, David A, Hofmann, Claudia, Schölmerich, Jürgen, Neumann, Inga D, Obermeier, Florian
Format: Article
Language:English
Subjects:
Adrenalectomy
Allergy and Immunology
Animals
Anti-Bacterial Agents - therapeutic use
Apoptosis
Bacteria - drug effects
Bacteria - isolation & purification
Bacterial Translocation
Chronic psychosocial stress
Colitis
Colitis - etiology
Colitis - immunology
Colitis - microbiology
Colitis - pathology
Colon - microbiology
Corticosterone - blood
Corticosterone - secretion
CSC
Epithelial Cells - pathology
Feces - microbiology
Immune Tolerance
Immunity, Mucosal
Intestinal barrier
Intestinal Mucosa - immunology
Intestinal Mucosa - microbiology
Lymph Nodes - microbiology
Male
Mesentery
Mice
Mice, Inbred C57BL
Permeability
Psychiatry
Social Dominance
Stress, Psychological - complications
Stress, Psychological - immunology
Stress, Psychological - physiopathology
Territoriality
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Summary:Highlights ► 10 h of psychosocial stress cause local colonic immunosuppression mediated by adrenal hormones. ► 10 h of psychosocial stress result in a reduction of colonic barrier functions. ► 10 h of psychosocial stress cause proliferation and translocation of commensal bacteria. ► Translocation of comensal bacteria is causal for the initiation of stress-induced colitis. ► Immune-modulatory effect of adrenal hormones is essential for development of full blown colitis.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2011.03.004