Detection of platelet-binding anti-measles and anti-rubella virus IgG antibodies in infants with vaccine-induced thrombocytopenic purpura

A 15-month-old infant presented with thrombocytopenic purpura after sequential administration of measles-rubella combined vaccine, varicella vaccine and mumps vaccine every 4 weeks. Her thrombocytopenia persisted for more than 12 months. Both anti-measles and anti-rubella virus IgG antibodies were d...

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Bibliographic Details
Published in:Vaccine 2011-07, Vol.29 (31), p.4878-4880
Main Authors: Okazaki, Naho, Takeguchi, Masahiro, Sonoda, Kohji, Handa, Yohsuke, Kakiuchi, Tatsuo, Miyahara, Hiroaki, Akiyoshi, Kensuke, Korematsu, Seigo, Suenobu, Soichi, Izumi, Tatsuro
Format: Article
Language:English
Subjects:
Allergy and Immunology
antibodies
Antibodies, Viral - blood
Applied microbiology
Biological and medical sciences
Blood Platelets - metabolism
blood serum
Detection from isolated platelets
Female
Fundamental and applied biological sciences. Psychology
Humans
immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin G - metabolism
Infant
Infants
Infections
ITP
Measles
Measles Vaccine - adverse effects
Measles Vaccine - immunology
Microbiology
Miscellaneous
MR vaccination
Mumps
patients
Platelet-binding anti-MR viruses IgG antibodies
Protein Binding
Purpura, Thrombocytopenic - chemically induced
Rubella Vaccine - adverse effects
Rubella Vaccine - immunology
thrombocytopenic purpura
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Combined - adverse effects
Vaccines, Combined - immunology
Varicella-zoster virus
Virology
viruses
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Summary:A 15-month-old infant presented with thrombocytopenic purpura after sequential administration of measles-rubella combined vaccine, varicella vaccine and mumps vaccine every 4 weeks. Her thrombocytopenia persisted for more than 12 months. Both anti-measles and anti-rubella virus IgG antibodies were detected in the patient's-isolated platelets on day 154 of illness, which were not detected when there was a reduction of the serum IgG antibody titers on days 298 and 373 of illness, respectively.We also detected the isolated platelet-binding anti-measles and anti-rubella virus IgG antibodies in two other pediatric patients. This is the first report demonstrating direct evidence of vaccine-induced thrombocytopenic purpura.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.04.036