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Detection of platelet-binding anti-measles and anti-rubella virus IgG antibodies in infants with vaccine-induced thrombocytopenic purpura
A 15-month-old infant presented with thrombocytopenic purpura after sequential administration of measles-rubella combined vaccine, varicella vaccine and mumps vaccine every 4 weeks. Her thrombocytopenia persisted for more than 12 months. Both anti-measles and anti-rubella virus IgG antibodies were d...
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Published in: | Vaccine 2011-07, Vol.29 (31), p.4878-4880 |
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creator | Okazaki, Naho Takeguchi, Masahiro Sonoda, Kohji Handa, Yohsuke Kakiuchi, Tatsuo Miyahara, Hiroaki Akiyoshi, Kensuke Korematsu, Seigo Suenobu, Soichi Izumi, Tatsuro |
description | A 15-month-old infant presented with thrombocytopenic purpura after sequential administration of measles-rubella combined vaccine, varicella vaccine and mumps vaccine every 4 weeks. Her thrombocytopenia persisted for more than 12 months. Both anti-measles and anti-rubella virus IgG antibodies were detected in the patient's-isolated platelets on day 154 of illness, which were not detected when there was a reduction of the serum IgG antibody titers on days 298 and 373 of illness, respectively.We also detected the isolated platelet-binding anti-measles and anti-rubella virus IgG antibodies in two other pediatric patients. This is the first report demonstrating direct evidence of vaccine-induced thrombocytopenic purpura. |
doi_str_mv | 10.1016/j.vaccine.2011.04.036 |
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Her thrombocytopenia persisted for more than 12 months. Both anti-measles and anti-rubella virus IgG antibodies were detected in the patient's-isolated platelets on day 154 of illness, which were not detected when there was a reduction of the serum IgG antibody titers on days 298 and 373 of illness, respectively.We also detected the isolated platelet-binding anti-measles and anti-rubella virus IgG antibodies in two other pediatric patients. This is the first report demonstrating direct evidence of vaccine-induced thrombocytopenic purpura.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2011.04.036</identifier><identifier>PMID: 21539881</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Allergy and Immunology ; antibodies ; Antibodies, Viral - blood ; Applied microbiology ; Biological and medical sciences ; Blood Platelets - metabolism ; blood serum ; Detection from isolated platelets ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; immunoglobulin G ; Immunoglobulin G - blood ; Immunoglobulin G - metabolism ; Infant ; Infants ; Infections ; ITP ; Measles ; Measles Vaccine - adverse effects ; Measles Vaccine - immunology ; Microbiology ; Miscellaneous ; MR vaccination ; Mumps ; patients ; Platelet-binding anti-MR viruses IgG antibodies ; Protein Binding ; Purpura, Thrombocytopenic - chemically induced ; Rubella Vaccine - adverse effects ; Rubella Vaccine - immunology ; thrombocytopenic purpura ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, Combined - adverse effects ; Vaccines, Combined - immunology ; Varicella-zoster virus ; Virology ; viruses</subject><ispartof>Vaccine, 2011-07, Vol.29 (31), p.4878-4880</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jul 12, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-c3f4567a00f72850950fda0cb1ac6d653c8f26bcf19027dadb7150f9d62cf92b3</citedby><cites>FETCH-LOGICAL-c533t-c3f4567a00f72850950fda0cb1ac6d653c8f26bcf19027dadb7150f9d62cf92b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24314768$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21539881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okazaki, Naho</creatorcontrib><creatorcontrib>Takeguchi, Masahiro</creatorcontrib><creatorcontrib>Sonoda, Kohji</creatorcontrib><creatorcontrib>Handa, Yohsuke</creatorcontrib><creatorcontrib>Kakiuchi, Tatsuo</creatorcontrib><creatorcontrib>Miyahara, Hiroaki</creatorcontrib><creatorcontrib>Akiyoshi, Kensuke</creatorcontrib><creatorcontrib>Korematsu, Seigo</creatorcontrib><creatorcontrib>Suenobu, Soichi</creatorcontrib><creatorcontrib>Izumi, Tatsuro</creatorcontrib><title>Detection of platelet-binding anti-measles and anti-rubella virus IgG antibodies in infants with vaccine-induced thrombocytopenic purpura</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>A 15-month-old infant presented with thrombocytopenic purpura after sequential administration of measles-rubella combined vaccine, varicella vaccine and mumps vaccine every 4 weeks. Her thrombocytopenia persisted for more than 12 months. Both anti-measles and anti-rubella virus IgG antibodies were detected in the patient's-isolated platelets on day 154 of illness, which were not detected when there was a reduction of the serum IgG antibody titers on days 298 and 373 of illness, respectively.We also detected the isolated platelet-binding anti-measles and anti-rubella virus IgG antibodies in two other pediatric patients. This is the first report demonstrating direct evidence of vaccine-induced thrombocytopenic purpura.</description><subject>Allergy and Immunology</subject><subject>antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - metabolism</subject><subject>blood serum</subject><subject>Detection from isolated platelets</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - metabolism</subject><subject>Infant</subject><subject>Infants</subject><subject>Infections</subject><subject>ITP</subject><subject>Measles</subject><subject>Measles Vaccine - adverse effects</subject><subject>Measles Vaccine - immunology</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>MR vaccination</subject><subject>Mumps</subject><subject>patients</subject><subject>Platelet-binding anti-MR viruses IgG antibodies</subject><subject>Protein Binding</subject><subject>Purpura, Thrombocytopenic - chemically induced</subject><subject>Rubella Vaccine - adverse effects</subject><subject>Rubella Vaccine - immunology</subject><subject>thrombocytopenic purpura</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, Combined - adverse effects</subject><subject>Vaccines, Combined - immunology</subject><subject>Varicella-zoster virus</subject><subject>Virology</subject><subject>viruses</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFktuKFDEQhhtR3HH1EdQGEa96rHQOnb5RZNV1YcGLdcG7kM5hNmNPZ0y6R-YRfGurndGFvVkIhBRfVarq_4viOYElASLerpc7bUwY3LIGQpbAlkDFg2JBZEOrmhP5sFhALVjFCHw_KZ7kvAYATkn7uDipCaetlGRR_P7oRmfGEIcy-nLb69H1bqy6MNgwrEo9jKHaOJ17l_FhD4E0da7vdbkLacrlxer8b7iLNiAVBjweA7n8Fcab8thmhRUn42w53qS46aLZj3HrhmDK7ZTw6KfFI6_77J4d79Pi-vOnb2dfqsuv5xdnHy4rwykdK0M946LRAL6pJYeWg7caTEe0EVZwaqSvRWc8aaFurLZdQxBpraiNb-uOnhZvDnW3Kf6cXB7VJmQzzzO4OGUlJQUmGW3uJxsmWykaguSrO-Q6TmnAMRRhbdMyxqVAih8ok2LOyXm1TWGj014RULOoaq2O21KzqAqYQlEx78Wx-tRtnP2f9U9FBF4fAZ2N7n3Sgwn5lmOUsEZI5F4eOK-j0quEzPUV_sQBCJv3hcT7A-FQgV1wSWUT3IC6hYQ2UTaGe5t9d6eC6QPKrPsfbu_y7V5UrhWoq9mjs0UJQXdKAvQPWqHicg</recordid><startdate>20110712</startdate><enddate>20110712</enddate><creator>Okazaki, Naho</creator><creator>Takeguchi, Masahiro</creator><creator>Sonoda, Kohji</creator><creator>Handa, Yohsuke</creator><creator>Kakiuchi, Tatsuo</creator><creator>Miyahara, Hiroaki</creator><creator>Akiyoshi, Kensuke</creator><creator>Korematsu, Seigo</creator><creator>Suenobu, Soichi</creator><creator>Izumi, Tatsuro</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110712</creationdate><title>Detection of platelet-binding anti-measles and anti-rubella virus IgG antibodies in infants with vaccine-induced thrombocytopenic purpura</title><author>Okazaki, Naho ; Takeguchi, Masahiro ; Sonoda, Kohji ; Handa, Yohsuke ; Kakiuchi, Tatsuo ; Miyahara, Hiroaki ; Akiyoshi, Kensuke ; Korematsu, Seigo ; Suenobu, Soichi ; Izumi, Tatsuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-c3f4567a00f72850950fda0cb1ac6d653c8f26bcf19027dadb7150f9d62cf92b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Allergy and Immunology</topic><topic>antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - metabolism</topic><topic>blood serum</topic><topic>Detection from isolated platelets</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okazaki, Naho</au><au>Takeguchi, Masahiro</au><au>Sonoda, Kohji</au><au>Handa, Yohsuke</au><au>Kakiuchi, Tatsuo</au><au>Miyahara, Hiroaki</au><au>Akiyoshi, Kensuke</au><au>Korematsu, Seigo</au><au>Suenobu, Soichi</au><au>Izumi, Tatsuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of platelet-binding anti-measles and anti-rubella virus IgG antibodies in infants with vaccine-induced thrombocytopenic purpura</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2011-07-12</date><risdate>2011</risdate><volume>29</volume><issue>31</issue><spage>4878</spage><epage>4880</epage><pages>4878-4880</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>A 15-month-old infant presented with thrombocytopenic purpura after sequential administration of measles-rubella combined vaccine, varicella vaccine and mumps vaccine every 4 weeks. Her thrombocytopenia persisted for more than 12 months. Both anti-measles and anti-rubella virus IgG antibodies were detected in the patient's-isolated platelets on day 154 of illness, which were not detected when there was a reduction of the serum IgG antibody titers on days 298 and 373 of illness, respectively.We also detected the isolated platelet-binding anti-measles and anti-rubella virus IgG antibodies in two other pediatric patients. This is the first report demonstrating direct evidence of vaccine-induced thrombocytopenic purpura.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21539881</pmid><doi>10.1016/j.vaccine.2011.04.036</doi><tpages>3</tpages></addata></record> |
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subjects | Allergy and Immunology antibodies Antibodies, Viral - blood Applied microbiology Biological and medical sciences Blood Platelets - metabolism blood serum Detection from isolated platelets Female Fundamental and applied biological sciences. Psychology Humans immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - metabolism Infant Infants Infections ITP Measles Measles Vaccine - adverse effects Measles Vaccine - immunology Microbiology Miscellaneous MR vaccination Mumps patients Platelet-binding anti-MR viruses IgG antibodies Protein Binding Purpura, Thrombocytopenic - chemically induced Rubella Vaccine - adverse effects Rubella Vaccine - immunology thrombocytopenic purpura Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Combined - adverse effects Vaccines, Combined - immunology Varicella-zoster virus Virology viruses |
title | Detection of platelet-binding anti-measles and anti-rubella virus IgG antibodies in infants with vaccine-induced thrombocytopenic purpura |
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