Radiological assessment of necrosis in glioblastoma : variability and prognostic value

In a previous study, we found that the extent of necrosis was the only radiological feature which correlated significantly with survival in patients with glioblastoma. The aim of this paper was to evaluate the variability and prognostic value of the extent of the necrotic area as seen on contrast-en...

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Bibliographic Details
Published in:Neuroradiology 1998-03, Vol.40 (3), p.150-153
Main Authors: PIERALLINI, A, BONAMINI, M, PANTANO, P, PALMEGGIANI, F, RAGUSO, M, OSTI, M. F, ANAVERI, G, BOZZAO, L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - pathology
Combined Modality Therapy
Contrast Media
Female
Gadolinium DTPA
Glioblastoma - diagnosis
Glioblastoma - mortality
Glioblastoma - therapy
Humans
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
Necrosis
Neurology
Prognosis
Supratentorial Neoplasms - diagnosis
Supratentorial Neoplasms - mortality
Supratentorial Neoplasms - therapy
Survival Analysis
Tomography, X-Ray Computed
Tumors of the nervous system. Phacomatoses
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Summary:In a previous study, we found that the extent of necrosis was the only radiological feature which correlated significantly with survival in patients with glioblastoma. The aim of this paper was to evaluate the variability and prognostic value of the extent of the necrotic area as seen on contrast-enhanced MRI and CT in a larger series. We studied 72 patients who underwent surgical removal of supratentorial glioblastomas and had CT and/or MRI with contrast medium before surgery; 38, all undergoing the same treatment (surgery plus radiotherapy), were followed clinically. Necrosis within the tumour varied greatly, ranging from none (only 1 case) to involvement of 76% of the tumour. Survival data in the subgroup suggested that only patients with a small area of necrosis (less than 35% of the tumour) had a significantly longer survival time. When necrosis involved more than 35% of the mass, patients had a shorter survival time, without any further correlation with the extent of necrosis.
ISSN:0028-3940
1432-1920
DOI:10.1007/s002340050556