Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A

Background: The available methods for measuring factor VIII (FVIII) activity suffer reportedly from lack of sensitivity and precision in the

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2011-08, Vol.9 (8), p.1549-1555
Main Authors: NINIVAGGI, M., DARGAUD, Y., Van OERLE, R., De LAAT, B., HEMKER, H. C., LINDHOUT, T.
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Blood Coagulation Tests
factor IXa‐driven thrombin generation
Factor VIII - analysis
Factor Xa - metabolism
France
FVIII‐assay
hemophilia A
Hemophilia A - blood
Hemophilia A - diagnosis
Humans
Kinetics
Middle Aged
Netherlands
Phenotype
Predictive Value of Tests
Reproducibility of Results
Sensitivity and Specificity
Severity of Illness Index
Thrombin - metabolism
Thromboplastin - metabolism
Young Adult
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Description
Summary:Background: The available methods for measuring factor VIII (FVIII) activity suffer reportedly from lack of sensitivity and precision in the
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/j.1538-7836.2011.04358.x