Effect on the quality of blood components after simulated blood transfusions using volumetric infusion pumps

BACKGROUND: It is unknown whether the use of volumetric infusion pumps for the transfusion of red blood cells (RBCs) or platelet (PLT) concentrates (PCs) affects the quality of the blood components. We therefore investigated the in vitro quality of these components after use of infusion pumps. STUDY...

Full description

Saved in:
Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2011-08, Vol.51 (8), p.1835-1839
Main Authors: Lieshout-Krikke, Ryanne W., van der Meer, Pieter F., Koopman, Maria M.W., de Korte, Dirk
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Annexin A5 - metabolism
Biological and medical sciences
Blood Component Transfusion - methods
Blood Component Transfusion - standards
Blood Flow Velocity
Blood Safety
Blood Volume - physiology
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Blood. Blood coagulation. Reticuloendothelial system
Computer Simulation
Erythrocytes - cytology
Erythrocytes - metabolism
Hemoglobins - analysis
Humans
Infusion Pumps
Materials Testing - methods
Medical sciences
Pharmacology. Drug treatments
Quality Control
Rheology
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND: It is unknown whether the use of volumetric infusion pumps for the transfusion of red blood cells (RBCs) or platelet (PLT) concentrates (PCs) affects the quality of the blood components. We therefore investigated the in vitro quality of these components after use of infusion pumps. STUDY DESIGN AND METHODS: Ten different volumetric infusion pumps were used to simulate transfusion with RBCs and PCs. To prevent donor‐dependent differences multiple units were pooled and divided into equal portions. The storage time of RBCs was 30 to 35 days (n = 10 experiments), and for PCs, either 2 (n = 5) or 7 days (n = 5). For RBCs an infusion rate of 100 or 300 mL/hr was used, and for PCs, 600 mL/hr. Transfusions without an infusion pump served as a reference. RESULTS: None of the infusion pumps induced an increase of free hemoglobin, annexin A5 binding, or formation of echinocytes in RBCs compared to reference units. In 2‐ and 7‐day‐old PCs no effect was shown on PLT concentration, annexin A5 binding, mean PLT volume, and morphology score compared to the reference. The CD62P expression of 2‐day‐old PCs was significantly lower after transfusion compared to the reference, that is, 11.7 ± 2.1% versus 8.1 ± 1.3% (p 
ISSN:0041-1132
1537-2995
DOI:10.1111/j.1537-2995.2010.03037.x