Preparation of α-Alkyl-β-Amino Acids via β-Alanine Ni(II) Complex

A new β-amino acrylic acid Ni(II) complex has been developed and used for the synthesis of α-alkyl-β-amino acids via alkylation with alkyl halides under operationally convenient conditions. The pivotal α-alkylated intermediate can be converted into the corresponding α-alkyl-β-amino acids via two ste...

Full description

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 2011-08, Vol.76 (16), p.6649-6656
Main Authors: Lin, Daizong, Lv, Li, Wang, Jiang, Ding, Xiao, Jiang, Hualiang, Liu, Hong
Format: Article
Language:English
Subjects:
Alkylation
Amino Acids - chemical synthesis
Amino Acids - chemistry
beta-Alanine - chemistry
Catalysis
Chemistry
Exact sciences and technology
Glycine - chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Nickel - chemistry
Noncondensed benzenic compounds
Organic chemistry
Organometallic Compounds - chemistry
Preparations and properties
Stereoisomerism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new β-amino acrylic acid Ni(II) complex has been developed and used for the synthesis of α-alkyl-β-amino acids via alkylation with alkyl halides under operationally convenient conditions. The pivotal α-alkylated intermediate can be converted into the corresponding α-alkyl-β-amino acids via two steps with a wide range of substituents.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo200971k