Importance of proper scaling of aerobic power when relating to cardiometabolic risk factors in children

Background: The relationship between cardiometabolic risk factors (CMRF) and aerobic power (VO2max) scaled as mL O2 per kilogram body mass is controversial because mass includes both fat and fat-free mass, and fat mass is independently associated with the CMRF.Aim: To examine common units used to sc...

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Bibliographic Details
Published in:Annals of human biology 2011-09, Vol.38 (5), p.647-654
Main Authors: McMurray, Robert G., Hosick, Peter A., Bugge, Anna
Format: Article
Language:English
Subjects:
2max
Adolescent
Aerobiosis
Anthropometry
Blood Pressure - physiology
body fat
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - physiopathology
Child
cholesterol
fat-free mass
Female
Humans
insulin resistance
Insulin Resistance - physiology
Male
Mean blood pressure
Metabolic Syndrome - epidemiology
Metabolic Syndrome - metabolism
Metabolic Syndrome - physiopathology
North Carolina - epidemiology
Oxygen Consumption - physiology
Risk Factors
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Summary:Background: The relationship between cardiometabolic risk factors (CMRF) and aerobic power (VO2max) scaled as mL O2 per kilogram body mass is controversial because mass includes both fat and fat-free mass, and fat mass is independently associated with the CMRF.Aim: To examine common units used to scale VO2max and their relationships to mean blood pressure (MBP), total cholesterol (TC), HDL cholesterol, triglycerides (TG), insulin resistance (HOMA-IR) and cumulative risk score (z-score).Subjects: 1784, 8-18 year-old youths, 938 girls and 886 boys.Methods: Fasting blood samples were obtained. VO2max was estimated in mL/min from cycle ergometry and scaled to body mass (kg), fat free mass (kgFFM), body surface area (m2), height (cm) and allometric (mL/kg0.67/min).Results: Unadjusted correlations between CMRF and many of the scaled VO2max units were significant (p < 0.0001), especially for MBP, HOMA-IR, HDL and z-score, with lower correlations for TC and TG. After adjusting for ancestry, sex, height and body fat associations were greatly weakened (r < 0.09), except for MBP.Conclusions: On a population basis, the physical characteristics of the child, especially body fat, are more related to CMRF than any scaled units of VO2max; thus care is needed when relating fitness and health issues.
ISSN:0301-4460
1464-5033
DOI:10.3109/03014460.2011.598561