Ischaemia-modified albumin levels in newborn jaundice before and after phototherapy

The aim of our study was to assess the effect of phototherapy (PT) on ischaemia‐modified albumin (IMA) and malondialdehyde (MDA) levels in hyperbilirubinemic full‐term newborns. The study was performed on 36 full‐term infants exposed to PT. The babies were aged 3 to 13 days. IMA and MDA levels of th...

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Bibliographic Details
Published in:Cell biochemistry and function 2011-08, Vol.29 (6), p.521-525
Main Authors: Erdem, S. S., Kurban, S., Altunhan, H., Annagür, A., Örs, R., Yerlikaya, F. H., Gökçe, R., Mehmetoğlu, İ.
Format: Article
Language:English
Subjects:
Antioxidants - chemistry
Bilirubin - blood
Colorimetry
Female
Humans
hyperbilirubinaemia
Infant, Newborn
ischaemia-modified albumin
Ischemia - blood
Jaundice, Neonatal - blood
Jaundice, Neonatal - therapy
Male
malondialdehyde
Malondialdehyde - blood
Oxidants - chemistry
Oxidative Stress
Phototherapy
Serum Albumin - metabolism
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Summary:The aim of our study was to assess the effect of phototherapy (PT) on ischaemia‐modified albumin (IMA) and malondialdehyde (MDA) levels in hyperbilirubinemic full‐term newborns. The study was performed on 36 full‐term infants exposed to PT. The babies were aged 3 to 13 days. IMA and MDA levels of the babies were determined before and after PT, by a colorimetric assay. IMA levels before and after PT were found as 0.424 ± 0.290 and 0.531 ± 0.262 absorbance units, respectively. Although IMA levels after PT were slightly higher, the difference was not statistically significant (p > 0.131). MDA levels before and after PT were found as 8.4 ± 1.8 µmol/l and 9.4 ± 1.5 µmol/l, respectively. Serum MDA concentrations were significantly higher after PT than before PT (p 
ISSN:0263-6484
1099-0844
DOI:10.1002/cbf.1786