Mass eradication of Helicobacter pylori : feasible and advisable?

Annual recurrence of H pylori infection is about 12% in developing countries.14 However, the most serious issue relates to development of bacterial resistance for not only H pylori but potentially many other bacteria. [...] we believe that although any public policy aimed at decreasing the prevalenc...

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Bibliographic Details
Published in:The Lancet (British edition) 2011-08, Vol.378 (9790), p.462-464
Main Authors: Mazzoleni, Luiz Edmundo, Francesconi, Carlos Fernando, Sander, Guilherme Becker
Format: Article
Language:English
Subjects:
2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage
Amoxicillin - administration & dosage
Amoxicillin - adverse effects
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Antibiotics
Cancer
Clarithromycin - administration & dosage
Clarithromycin - adverse effects
Developing countries
Drug Administration Schedule
Drug Therapy, Combination
Drugs, Generic
Feasibility Studies
Female
Generic drugs
Health Policy - trends
Helicobacter Infections - drug therapy
Helicobacter Infections - economics
Helicobacter pylori - drug effects
Humans
Industrialized nations
Internal Medicine
Lansoprazole
Latin America - epidemiology
LDCs
Male
Metronidazole - administration & dosage
Mortality
Proton Pump Inhibitors - administration & dosage
Public policy
Randomized Controlled Trials as Topic
Stomach Neoplasms - microbiology
Stomach Neoplasms - mortality
Stomach Neoplasms - prevention & control
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Summary:Annual recurrence of H pylori infection is about 12% in developing countries.14 However, the most serious issue relates to development of bacterial resistance for not only H pylori but potentially many other bacteria. [...] we believe that although any public policy aimed at decreasing the prevalence of H pylori infection could lead to reductions in gastric cancer and peptic ulcer, the risks associated with antibiotic use might represent an important limitation to such a strategy.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(11)61099-4