Sebaceous gland loss and inflammation in scarring alopecia: A potential role in pathogenesis

Background Primary scarring alopecia (SA) comprises a group of disorders with poorly defined origins. Improving diagnostic and therapeutic capabilities requires a better understanding of their pathogenesis. Objectives We sought to assess the frequency of sebaceous gland loss in SA and to identify th...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2011-09, Vol.65 (3), p.597-603
Main Authors: Al-Zaid, Tariq, MD, Vanderweil, Stefan, BA, Zembowicz, Artur, MD, PhD, Lyle, Stephen, MD, PhD
Format: Article
Language:English
Subjects:
Alopecia - complications
Alopecia - pathology
Alopecia - physiopathology
Biological and medical sciences
Cicatrix - pathology
Dermatology
Hair and nails disorders
Hair Follicle - pathology
Humans
Inflammation
Medical sciences
pathogenesis
pathology
scarring alopecia
sebaceous gland
Sebaceous Glands - pathology
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Summary:Background Primary scarring alopecia (SA) comprises a group of disorders with poorly defined origins. Improving diagnostic and therapeutic capabilities requires a better understanding of their pathogenesis. Objectives We sought to assess the frequency of sebaceous gland loss in SA and to identify the role of sebaceous gland and sebaceous gland duct inflammation in the pathogenesis of SA. Methods Ninety specimens submitted with a clinical history of alopecia, both scarring and nonscarring, were reviewed. Samples were scored based on sebaceous gland, sebaceous duct, and follicle inflammation. Results Sebaceous gland loss was much more common in cases of SA (>53% of follicles on average) than non-SA (
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2010.09.774