Factors predictive of breast cancer in open biopsy in cases with atypical ductal hyperplasia diagnosed by ultrasound-guided core needle biopsy

• Published in: European journal of surgical oncology 2011-09, Vol.37 (9), p.758-764
• Main Authors: Hong, Z.-J, Chu, C.-H, Fan, H.-L, Hsu, H.-M, Chen, C.-J, Chan, D.-C, Yu, J.-C
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Atypical ductal hyperplasia; Biopsy; Biopsy, Needle; Breast - pathology; Breast Neoplasms - diagnosis; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Core needle biopsy; Female; Hematology, Oncology and Palliative Medicine; Humans; Hyperplasia; Mammography; Middle Aged; Precancerous Conditions - diagnosis; Precancerous Conditions - pathology; Surgery; Ultrasonography, Interventional; Ultrasound
• ISSN: 0748-7983; 1532-2157
• DOI: 10.1016/j.ejso.2011.06.014

Abstract Aims The purpose of the study was to explore factors predictive of breast cancer as diagnosed by excision biopsy in cases with a diagnosis of atypical ductal hyperplasia (ADH) on ultrasound-guided core needle biopsy (CNB). Patients and methods We carried out diagnosis of breast lesions by ultrasound-guided CNB in a single hospital in Taiwan from November 2003 to October 2009. Patients who were diagnosed with ADH and subsequently underwent excision biopsy were included in this study ( n  = 124). Results Fifty-six of the 124 patients who were included (45.2%) had cancer, and the remaining 68 had benign lesions. By multivariate analysis of all clinical characteristics and on the basis of the imaging features in these cases, older patient age (≥50 y/o, OR: 3.910, p  = 0.005), larger tumour size (≥15 mm, OR: 3.398, p  = 0.013), and the presence of architectural distortion by mammography (OR: 10.7, p  = 0.036) were found likely to be associated with breast cancer. Conclusions Open biopsy is necessary in patients who were diagnosed with ADH on CNB. Older patients (≥50 y/o), with a larger tumour size (≥15 mm) and an abnormal mammography are especially likely to have breast cancer.