Sympathetic Reinnervation 1 Year After Heart Transplantation, Assessed Using Iodine-123 Metaiodobenzylguanidine Imaging

Abstract Complete allograft denervation occurs during heart transplantation (HT). Partial ventricular sympathetic reinnervation that may develop after transplantation can be measured using iodine-123 meta iodobenzylguanidine (MIBG) uptake. Previous studies have suggested that reinnervation is likely...

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Bibliographic Details
Published in:Transplantation proceedings 2011-07, Vol.43 (6), p.2247-2248
Main Authors: Buendia-Fuentes, F, Almenar, L, Ruiz, C, Vercher, J.L, Sánchez-Lázaro, I, Martínez-Dolz, L, Navarro, J, Bello, P, Salvador, A
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Adult
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Heart - innervation
Heart Transplantation
Humans
Male
Medical sciences
Middle Aged
Nerve Regeneration
Radionuclide Imaging
Radiopharmaceuticals
Spain
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Sympathetic Nervous System - diagnostic imaging
Time Factors
Tissue, organ and graft immunology
Treatment Outcome
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Summary:Abstract Complete allograft denervation occurs during heart transplantation (HT). Partial ventricular sympathetic reinnervation that may develop after transplantation can be measured using iodine-123 meta iodobenzylguanidine (MIBG) uptake. Previous studies have suggested that reinnervation is likely to be a slow process, only occurring after 1 year posttransplantation. However, the reinnervation prevalence at 1 year after HT remains unknown. This study sought to determine sympathetic reinnervation measured by MIBG at 12 months after surgery. We performed serial cardiac MIBG imaging in 45 cardiac transplant recipients, including 32 males and 13 females, early (2 months) and late (12 months) after the operation. The intensity of myocardial MIBG uptaken was quantified by heart-to-mediastinum ratios (HMR). Reinnervation was considered when the HMR was >1.3. HMR was significantly higher at 12 months: 1.16 ± 0.10 at 2 vs 1.30 ± 0.15 at 12 months ( P < .001). Eighteen (40%) of 45 subjects developed visible cardiac MIBG uptake at 1 year after transplantation with HMR >1.3. In conclusion, partial sympathetic reinnervation increases with time after HT; it was seen in 40% of patients at 1 year after the operation.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2011.05.020