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Predictors of acute kidney injury post-cardiopulmonary bypass in children
Objective To investigate the incidence, implicating factors and outcome of acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in patients admitted to a pediatric cardiothoracic intensive care unit (ICU). Materials and methods Design: A retrospective review study. Setting: A 10-bed cardioth...
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| Published in: | Clinical and experimental nephrology 2011-08, Vol.15 (4), p.529-534 |
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| container_end_page | 534 |
| container_issue | 4 |
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| container_title | Clinical and experimental nephrology |
| container_volume | 15 |
| creator | Sethi, Sidharth Kumar Goyal, Deepak Yadav, Dinesh Kumar Shukla, Umesh Kajala, Pyare Lal Gupta, V. K. Grover, Vijay Kapoor, Pragati Juneja, Atul |
| description | Objective
To investigate the incidence, implicating factors and outcome of acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in patients admitted to a pediatric cardiothoracic intensive care unit (ICU).
Materials and methods
Design:
A retrospective review study.
Setting:
A 10-bed cardiothoracic ICU.
Patients:
One hundred and twenty-four children ( |
| doi_str_mv | 10.1007/s10157-011-0440-2 |
| format | article |
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To investigate the incidence, implicating factors and outcome of acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in patients admitted to a pediatric cardiothoracic intensive care unit (ICU).
Materials and methods
Design:
A retrospective review study.
Setting:
A 10-bed cardiothoracic ICU.
Patients:
One hundred and twenty-four children (<18 years of age) admitted to the cardiothoracic ICU following CPB between January 2007 and December 2009.
Methods:
Age, sex, diagnosis, baseline and post-surgery hemoglobin, total leukocyte count, platelet count and biochemistry were recorded. Baseline and postoperative urea (mg/dl), creatinine (mg/dl), urine output (ml/kg/h) and inotrope dose were also recorded daily. The duration of CPB was noted. Postoperative cardiac, renal, hepatic, neurologic and respiratory dysfunctions were recorded.
Results
Seven (5%) children developed AKI stage I, five children (4%) developed AKI stage II and two children developed AKI stage III (2%). All patients with AKI had a longer stay in hospital and increased mortality. Two children required dialysis for AKI and none developed chronic renal impairment. All patients with AKI stage III died during the ICU stay. Using stepwise regression, younger age (<1 year), weight <10 kg, pump failure, sepsis and duration of CPB >90 min were significant risk factors identified for developing AKI.
Conclusions
AKI is common and occurred in 11% of our patients following CPB; however, AKI requiring renal replacement therapy is uncommon.</description><identifier>ISSN: 1342-1751</identifier><identifier>EISSN: 1437-7799</identifier><identifier>DOI: 10.1007/s10157-011-0440-2</identifier><identifier>PMID: 21479987</identifier><identifier>CODEN: CENPFV</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Acute Kidney Injury - etiology ; Acute Kidney Injury - mortality ; Adolescent ; Cardiopulmonary Bypass - adverse effects ; Child ; Child, Preschool ; Female ; Heart Defects, Congenital - surgery ; Humans ; Infant ; Intensive Care Units, Pediatric ; Length of Stay ; Male ; Medicine ; Medicine & Public Health ; Nephrology ; Original Article ; Renal Dialysis ; Retrospective Studies ; Sepsis - complications ; Treatment Outcome ; Urology</subject><ispartof>Clinical and experimental nephrology, 2011-08, Vol.15 (4), p.529-534</ispartof><rights>Japanese Society of Nephrology 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-71676518dfd3e5a003ba3cbee4e0f41beea9cfe8562f4f48d9f34d301adadfd73</citedby><cites>FETCH-LOGICAL-c521t-71676518dfd3e5a003ba3cbee4e0f41beea9cfe8562f4f48d9f34d301adadfd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21479987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sethi, Sidharth Kumar</creatorcontrib><creatorcontrib>Goyal, Deepak</creatorcontrib><creatorcontrib>Yadav, Dinesh Kumar</creatorcontrib><creatorcontrib>Shukla, Umesh</creatorcontrib><creatorcontrib>Kajala, Pyare Lal</creatorcontrib><creatorcontrib>Gupta, V. K.</creatorcontrib><creatorcontrib>Grover, Vijay</creatorcontrib><creatorcontrib>Kapoor, Pragati</creatorcontrib><creatorcontrib>Juneja, Atul</creatorcontrib><title>Predictors of acute kidney injury post-cardiopulmonary bypass in children</title><title>Clinical and experimental nephrology</title><addtitle>Clin Exp Nephrol</addtitle><addtitle>Clin Exp Nephrol</addtitle><description>Objective
To investigate the incidence, implicating factors and outcome of acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in patients admitted to a pediatric cardiothoracic intensive care unit (ICU).
Materials and methods
Design:
A retrospective review study.
Setting:
A 10-bed cardiothoracic ICU.
Patients:
One hundred and twenty-four children (<18 years of age) admitted to the cardiothoracic ICU following CPB between January 2007 and December 2009.
Methods:
Age, sex, diagnosis, baseline and post-surgery hemoglobin, total leukocyte count, platelet count and biochemistry were recorded. Baseline and postoperative urea (mg/dl), creatinine (mg/dl), urine output (ml/kg/h) and inotrope dose were also recorded daily. The duration of CPB was noted. Postoperative cardiac, renal, hepatic, neurologic and respiratory dysfunctions were recorded.
Results
Seven (5%) children developed AKI stage I, five children (4%) developed AKI stage II and two children developed AKI stage III (2%). All patients with AKI had a longer stay in hospital and increased mortality. Two children required dialysis for AKI and none developed chronic renal impairment. All patients with AKI stage III died during the ICU stay. Using stepwise regression, younger age (<1 year), weight <10 kg, pump failure, sepsis and duration of CPB >90 min were significant risk factors identified for developing AKI.
Conclusions
AKI is common and occurred in 11% of our patients following CPB; however, AKI requiring renal replacement therapy is uncommon.</description><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - mortality</subject><subject>Adolescent</subject><subject>Cardiopulmonary Bypass - adverse effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Heart Defects, Congenital - surgery</subject><subject>Humans</subject><subject>Infant</subject><subject>Intensive Care Units, Pediatric</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Renal Dialysis</subject><subject>Retrospective Studies</subject><subject>Sepsis - complications</subject><subject>Treatment Outcome</subject><subject>Urology</subject><issn>1342-1751</issn><issn>1437-7799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kM1PwyAchonRuDn9A7yYxosnlF-B0h7N4seSJXrQM2F8aGdXKrSH_feydGpi4olf4Hlf4EHoHMg1ECJuIhDgAhMATBgjOD9AU2BUYCGq6jDNlOUYBIcJOolxTQgpK14do0kOLBGlmKLFc7Cm1r0PMfMuU3robfZRm9Zus7pdD2GbdT72WKtgat8Nzca3Km2utp2KMSGZfq8bE2x7io6caqI9268z9Hp_9zJ_xMunh8X8dok1z6HHAgpRcCiNM9RyRQhdKapX1jJLHIM0qEo7W_Iid8yx0lSOMkMJKKNSRtAZuhp7u-A_Bxt7uamjtk2jWuuHKMuS5UXFiyqRl3_ItR9Cmx6XIFpyJihLEIyQDj7GYJ3sQr1JX5RA5M6yHC3LZFnuLMs8ZS72xcNqY81P4ltrAvIRiOmofbPh9-b_W78Akm6Isg</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Sethi, Sidharth Kumar</creator><creator>Goyal, Deepak</creator><creator>Yadav, Dinesh Kumar</creator><creator>Shukla, Umesh</creator><creator>Kajala, Pyare Lal</creator><creator>Gupta, V. K.</creator><creator>Grover, Vijay</creator><creator>Kapoor, Pragati</creator><creator>Juneja, Atul</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Predictors of acute kidney injury post-cardiopulmonary bypass in children</title><author>Sethi, Sidharth Kumar ; Goyal, Deepak ; Yadav, Dinesh Kumar ; Shukla, Umesh ; Kajala, Pyare Lal ; Gupta, V. K. ; Grover, Vijay ; Kapoor, Pragati ; Juneja, Atul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-71676518dfd3e5a003ba3cbee4e0f41beea9cfe8562f4f48d9f34d301adadfd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Kidney Injury - etiology</topic><topic>Acute Kidney Injury - mortality</topic><topic>Adolescent</topic><topic>Cardiopulmonary Bypass - adverse effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Heart Defects, Congenital - surgery</topic><topic>Humans</topic><topic>Infant</topic><topic>Intensive Care Units, Pediatric</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Renal Dialysis</topic><topic>Retrospective Studies</topic><topic>Sepsis - complications</topic><topic>Treatment Outcome</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sethi, Sidharth Kumar</creatorcontrib><creatorcontrib>Goyal, Deepak</creatorcontrib><creatorcontrib>Yadav, Dinesh Kumar</creatorcontrib><creatorcontrib>Shukla, Umesh</creatorcontrib><creatorcontrib>Kajala, Pyare Lal</creatorcontrib><creatorcontrib>Gupta, V. K.</creatorcontrib><creatorcontrib>Grover, Vijay</creatorcontrib><creatorcontrib>Kapoor, Pragati</creatorcontrib><creatorcontrib>Juneja, Atul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sethi, Sidharth Kumar</au><au>Goyal, Deepak</au><au>Yadav, Dinesh Kumar</au><au>Shukla, Umesh</au><au>Kajala, Pyare Lal</au><au>Gupta, V. K.</au><au>Grover, Vijay</au><au>Kapoor, Pragati</au><au>Juneja, Atul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of acute kidney injury post-cardiopulmonary bypass in children</atitle><jtitle>Clinical and experimental nephrology</jtitle><stitle>Clin Exp Nephrol</stitle><addtitle>Clin Exp Nephrol</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>15</volume><issue>4</issue><spage>529</spage><epage>534</epage><pages>529-534</pages><issn>1342-1751</issn><eissn>1437-7799</eissn><coden>CENPFV</coden><abstract>Objective
To investigate the incidence, implicating factors and outcome of acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in patients admitted to a pediatric cardiothoracic intensive care unit (ICU).
Materials and methods
Design:
A retrospective review study.
Setting:
A 10-bed cardiothoracic ICU.
Patients:
One hundred and twenty-four children (<18 years of age) admitted to the cardiothoracic ICU following CPB between January 2007 and December 2009.
Methods:
Age, sex, diagnosis, baseline and post-surgery hemoglobin, total leukocyte count, platelet count and biochemistry were recorded. Baseline and postoperative urea (mg/dl), creatinine (mg/dl), urine output (ml/kg/h) and inotrope dose were also recorded daily. The duration of CPB was noted. Postoperative cardiac, renal, hepatic, neurologic and respiratory dysfunctions were recorded.
Results
Seven (5%) children developed AKI stage I, five children (4%) developed AKI stage II and two children developed AKI stage III (2%). All patients with AKI had a longer stay in hospital and increased mortality. Two children required dialysis for AKI and none developed chronic renal impairment. All patients with AKI stage III died during the ICU stay. Using stepwise regression, younger age (<1 year), weight <10 kg, pump failure, sepsis and duration of CPB >90 min were significant risk factors identified for developing AKI.
Conclusions
AKI is common and occurred in 11% of our patients following CPB; however, AKI requiring renal replacement therapy is uncommon.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>21479987</pmid><doi>10.1007/s10157-011-0440-2</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1342-1751 |
| ispartof | Clinical and experimental nephrology, 2011-08, Vol.15 (4), p.529-534 |
| issn | 1342-1751 1437-7799 |
| language | eng |
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| source | Springer Link |
| subjects | Acute Kidney Injury - etiology Acute Kidney Injury - mortality Adolescent Cardiopulmonary Bypass - adverse effects Child Child, Preschool Female Heart Defects, Congenital - surgery Humans Infant Intensive Care Units, Pediatric Length of Stay Male Medicine Medicine & Public Health Nephrology Original Article Renal Dialysis Retrospective Studies Sepsis - complications Treatment Outcome Urology |
| title | Predictors of acute kidney injury post-cardiopulmonary bypass in children |
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