Measurements of serum cystatin C concentrations underestimate renal dysfunction in pediatric patients with chronic kidney disease

• Published in: Clinical and experimental nephrology 2011-08, Vol.15 (4), p.535-538
• Main Authors: Uemura, Osamu, Ushijima, Katsumi, Nagai, Takuhito, Yamada, Takuji, Yamakawa, Satoshi, Hibi, Yoshiko, Hayakawa, Hideki, Nabeta, Yayoi, Shinkai, Yoshiko, Koike, Kouichi, Kuwabara, Masaki
• Format: Article
• Language: English
• Subjects: Child; Child, Preschool; Creatinine - blood; Cystatin C - blood; False Negative Reactions; Female; Glomerular Filtration Rate; Humans; Kidney - physiopathology; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - physiopathology; Male; Mathematical Concepts; Medicine; Medicine & Public Health; Nephrology; Original Article; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - physiopathology; Urology
• ISSN: 1342-1751; 1437-7799
• DOI: 10.1007/s10157-011-0446-9

Background In our clinical experience, cystatin C (CysC) concentrations are not as high as expected in patients with chronic kidney disease (CKD) and high-stage renal dysfunction. We therefore investigated whether measurements of serum CysC result in an underestimation of renal dysfunction in pediatric patients with CKD. Methods Glomerular filtration rate (GFR) was estimated from serum creatinine (Cr) concentration, using the equation Cr-GFR (%) = [0.30 × body length (m)/serum Cr] × 100; and from serum CysC concentration, using the equation Cys-GFR (%) = (0.70/serum CysC) × 100. We investigated the relationship between GFR estimated by these 2 equations. Patients aged 2–12 years were assorted into 5 groups, based on GFR-Cr categories of