Cognitive dysfunction and multiple sclerosis: developing a rationale for considering the efficacy of exercise training

Cognitive impairment is a prevalent, disabling, and poorly managed consequence of multiple sclerosis (MS). This underscores the importance of considering alternative approaches, such as exercise training, for managing cognitive impairment in persons with MS. The consideration of exercise training is...

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Bibliographic Details
Published in:Multiple sclerosis 2011-09, Vol.17 (9), p.1034-1040
Main Authors: Motl, Robert W, Sandroff, Brian M, Benedict, Ralph HB
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cognition Disorders - therapy
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Exercise - psychology
Exercise Therapy
Humans
Medical sciences
Multiple Sclerosis - therapy
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Physical Fitness - psychology
Randomized Controlled Trials as Topic
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Summary:Cognitive impairment is a prevalent, disabling, and poorly managed consequence of multiple sclerosis (MS). This underscores the importance of considering alternative approaches, such as exercise training, for managing cognitive impairment in persons with MS. The consideration of exercise training is warranted based on evidence summarized in literature reviews and meta-analyses that (1) aerobic fitness, physical activity, and exercise training are associated with better cognitive function in older adults; and (2) exercise training has comparable effects on mobility and quality of life outcomes in older adults and persons with MS. To date, research examining aerobic fitness, physical activity, and exercise training effects on cognition in MS is nascent and mostly includes cross-sectional designs that provide preliminary evidence for a well-designed randomized controlled trial (RCT). We believe that a future RCT should adopt research methodologies and practices from gerontology when examining exercise training and cognition in MS. This will maximize the potential for successfully generating a body of knowledge on exercise training and cognition with the potential for impacting the lives of persons with MS.
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458511409612