Retrospective analysis of prognostic outcome of gastric cancer in young patients

• Published in: International journal of clinical oncology 2011-08, Vol.16 (4), p.328-334
• Main Authors: Nakamura, Rieko, Saikawa, Yoshiro, Takahashi, Tsunehiro, Takeuchi, Hiroya, Asanuma, Humiki, Yamada, Yoshinori, Kitagawa, Yuko
• Format: Article
• Language: English
• Subjects: Adult; Age; Age Factors; Aged; Aged, 80 and over; Cancer; Cancer Research; Female; Humans; Male; Medical prognosis; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Oncology; Original Article; Prognosis; Retrospective Studies; Sex Factors; Stomach; Stomach Neoplasms - epidemiology; Stomach Neoplasms - pathology; Surgical Oncology; Survival Analysis; Treatment Outcome; Young Adult
• ISSN: 1341-9625; 1437-7772
• DOI: 10.1007/s10147-011-0185-7

Background It has been suggested that gastric cancer in young patients has a worse prognosis than in older patients, but this is controversial. This retrospective investigation was undertaken to understand the clinicopathological features and identify the prognostic factors of gastric cancer in young patients. Methods Patients included in this study were those treated and followed up for gastric cancer from 1989 to 2005. Operative records, clinical, pathological, and follow-up data were reviewed. The critical age cut-off value for obtaining distinctive prognoses was 34 years. Results Of 1730 gastric cancer patients whose records were reviewed, 27 were less than 34 years old (YGC group). The YGC group contained significantly higher percentages of females, stage IV, macroscopic type 4 tumors, poorly differentiated histology, peritoneal dissemination, and epigastric pain symptoms than the gastric cancer group aged 34 years or more (OGC group). Survival in the YGC group was significantly worse than in the OGC group ( p  = 0.0363). Ten-year survival was 68.5% in the YGC group and 81.8% in the OGC group. Survival in the YGC group was poorer for the stage IV patients, compared with OGC patients, especially for the stage IV patients with peritoneal dissemination and without liver metastases (H0P1 patients) ( p  = 0.049). Conclusions Age in gastric cancer affects the prognosis, which in gastric cancer patients less than 34 years old was significantly poorer than for older patients, because of the high incidence of stage IV cancer with peritoneal dissemination in gastric cancer patients less than 34 years old.