Leptin-programmed rats respond to cold exposure changing hypothalamic leptin receptor and thyroid function differently from cold-exposed controls

We showed that neonatal leptin treatment programmes for hyperleptinemia and central leptin resistance both at 30days-old and adulthood, while programmes for lower serum T3 at 30days-old, but higher thyroid hormones (TH) at adulthood. As in these animals, acute cold at 30days-old normalized leptinemi...

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Bibliographic Details
Published in:Regulatory peptides 2011-11, Vol.171 (1-3), p.58-64
Main Authors: Dutra, Sheila Cristina Potente, de Moura, Egberto Gaspar, Lisboa, Patricia Cristina, Trevenzoli, Isis Hara, Passos, Magna Cottini Fonseca
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Catecholamine
Catecholamines - metabolism
Cold
Cold Temperature - adverse effects
Deiodinase
Fundamental and applied biological sciences. Psychology
Glycerolphosphate Dehydrogenase - metabolism
Hypothalamus - drug effects
Hypothalamus - metabolism
Iodide Peroxidase - metabolism
Leptin - administration & dosage
Leptin receptor
Male
Programming
Rats
Rats, Wistar
Receptors, Leptin - metabolism
Stress, Physiological
Thyroid
Thyroid Function Tests
Thyroid Hormones - metabolism
Vertebrates: endocrinology
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Summary:We showed that neonatal leptin treatment programmes for hyperleptinemia and central leptin resistance both at 30days-old and adulthood, while programmes for lower serum T3 at 30days-old, but higher thyroid hormones (TH) at adulthood. As in these animals, acute cold at 30days-old normalized leptinemia and restored the expression of hypothalamic leptin receptor (OBR), here we evaluate the effect of cold exposure on the thyroid function and OBR in adult rats programmed by neonatal hyperleptinemia. Pups were divided into 2 groups: Lep-injected with leptin (8μg/100g/BW, sc) for the first 10days of lactation, and C-injected with saline. At 150days, both groups were subdivided into: LepC and CC, which were exposed to 8°C for 12h. Serum leptin, TH, TSH, liver type I and brown adipose tissue (BAT) type II deiodinases (D1 and D2) activities, liver mitochondrial alpha-glycerol-3-phosphate dehydrogenase (mGPD) activity and adrenal catecholamine content were measured. Hypothalamic and thyroid OBR protein contents were evaluated. Differences were significant when p
ISSN:0167-0115
1873-1686
DOI:10.1016/j.regpep.2011.07.005