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Combined Blockade of Serotonergic and Muscarinic Transmission Disrupts the Anterior Thalamic Head Direction Signal
Head direction (HD) cells have been speculated to be part of a network mediating navigational behavior. Previous work has shown that combined administration of serotonergic and muscarinic antagonists eliminates hippocampal theta activity and produces navigational deficits more severe than blockade o...
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| Published in: | Behavioral neuroscience 2008-12, Vol.122 (6), p.1226-1235 |
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| container_end_page | 1235 |
| container_issue | 6 |
| container_start_page | 1226 |
| container_title | Behavioral neuroscience |
| container_volume | 122 |
| creator | Sandoval, Kate McDaniel, Kathrine M Murawski, Nathen J Doerr, Celeste E Calton, Jeffrey L |
| description | Head direction
(HD) cells have been speculated to be part of a network mediating navigational
behavior. Previous work has shown that combined administration of serotonergic
and muscarinic antagonists eliminates hippocampal theta activity and produces
navigational deficits more severe than blockade of either neurotransmitter
system alone. The authors sought to assess this effect on the directional
characteristics of HD cells. HD cells were recorded from the anterior dorsal
thalamus of Long-Evans rats before and after administration of the serotonergic
antagonist methiothepin, the muscarinic antagonist scopolamine, both drugs, or
saline. Combined drug administration produced HD cells with preferred directions
that drifted within recording sessions. In addition, cells showed shifts in the
preferred directions at the start of a session relative to the position of the
major landmarks, suggesting that combined drug administration led to deficits in
landmark control of the HD system. Single drug exposures to methiothepin or
scopolamine did not noticeably affect the directional characteristics of HD
cells. This finding that navigation-impairing drugs can disrupt the HD signal
provides further evidence that this network plays an important role in
navigational behavior. |
| doi_str_mv | 10.1037/a0013138 |
| format | article |
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(HD) cells have been speculated to be part of a network mediating navigational
behavior. Previous work has shown that combined administration of serotonergic
and muscarinic antagonists eliminates hippocampal theta activity and produces
navigational deficits more severe than blockade of either neurotransmitter
system alone. The authors sought to assess this effect on the directional
characteristics of HD cells. HD cells were recorded from the anterior dorsal
thalamus of Long-Evans rats before and after administration of the serotonergic
antagonist methiothepin, the muscarinic antagonist scopolamine, both drugs, or
saline. Combined drug administration produced HD cells with preferred directions
that drifted within recording sessions. In addition, cells showed shifts in the
preferred directions at the start of a session relative to the position of the
major landmarks, suggesting that combined drug administration led to deficits in
landmark control of the HD system. Single drug exposures to methiothepin or
scopolamine did not noticeably affect the directional characteristics of HD
cells. This finding that navigation-impairing drugs can disrupt the HD signal
provides further evidence that this network plays an important role in
navigational behavior.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/a0013138</identifier><identifier>PMID: 19045942</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Acetylcholine ; Action Potentials - drug effects ; Action Potentials - physiology ; Animal ; Animal Migratory Behavior ; Animals ; Antagonist drugs ; Anterior Thalamic Nuclei - cytology ; Anterior Thalamic Nuclei - drug effects ; Anterior Thalamic Nuclei - physiology ; Behavior, Animal - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Cholinergic Agents - metabolism ; Drug Combinations ; Female ; Fundamental and applied biological sciences. Psychology ; Head Movements - drug effects ; Head Movements - physiology ; Male ; Methiothepin - pharmacology ; Motor Activity - drug effects ; Muscarinic Antagonists - pharmacology ; N-Methylscopolamine - pharmacology ; Neurons ; Neurons - drug effects ; Neurons - physiology ; Neurosciences ; Neurotransmitters ; Orientation - drug effects ; Orientation - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Long-Evans ; Rodents ; Serotonin ; Serotonin - metabolism ; Serotonin Antagonists - pharmacology ; Space Perception - drug effects ; Space Perception - physiology ; Spatial Orientation (Perception) ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Theta Rhythm</subject><ispartof>Behavioral neuroscience, 2008-12, Vol.122 (6), p.1226-1235</ispartof><rights>2008 American Psychological Association</rights><rights>2009 INIST-CNRS</rights><rights>Copyright American Psychological Association Dec 2008</rights><rights>2008, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a466t-ae74a2b6ef628ab662ba6fa9b8d0a13d46ab288f0f6cb2867c2d18c947dcc3f53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20960162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19045942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kelly, Anne E</contributor><contributor>Disterhoft, John F</contributor><creatorcontrib>Sandoval, Kate</creatorcontrib><creatorcontrib>McDaniel, Kathrine M</creatorcontrib><creatorcontrib>Murawski, Nathen J</creatorcontrib><creatorcontrib>Doerr, Celeste E</creatorcontrib><creatorcontrib>Calton, Jeffrey L</creatorcontrib><title>Combined Blockade of Serotonergic and Muscarinic Transmission Disrupts the Anterior Thalamic Head Direction Signal</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Head direction
(HD) cells have been speculated to be part of a network mediating navigational
behavior. Previous work has shown that combined administration of serotonergic
and muscarinic antagonists eliminates hippocampal theta activity and produces
navigational deficits more severe than blockade of either neurotransmitter
system alone. The authors sought to assess this effect on the directional
characteristics of HD cells. HD cells were recorded from the anterior dorsal
thalamus of Long-Evans rats before and after administration of the serotonergic
antagonist methiothepin, the muscarinic antagonist scopolamine, both drugs, or
saline. Combined drug administration produced HD cells with preferred directions
that drifted within recording sessions. In addition, cells showed shifts in the
preferred directions at the start of a session relative to the position of the
major landmarks, suggesting that combined drug administration led to deficits in
landmark control of the HD system. Single drug exposures to methiothepin or
scopolamine did not noticeably affect the directional characteristics of HD
cells. This finding that navigation-impairing drugs can disrupt the HD signal
provides further evidence that this network plays an important role in
navigational behavior.</description><subject>Acetylcholine</subject><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>Animal</subject><subject>Animal Migratory Behavior</subject><subject>Animals</subject><subject>Antagonist drugs</subject><subject>Anterior Thalamic Nuclei - cytology</subject><subject>Anterior Thalamic Nuclei - drug effects</subject><subject>Anterior Thalamic Nuclei - physiology</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cholinergic Agents - metabolism</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Head Movements - drug effects</subject><subject>Head Movements - physiology</subject><subject>Male</subject><subject>Methiothepin - pharmacology</subject><subject>Motor Activity - drug effects</subject><subject>Muscarinic Antagonists - pharmacology</subject><subject>N-Methylscopolamine - pharmacology</subject><subject>Neurons</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Neurosciences</subject><subject>Neurotransmitters</subject><subject>Orientation - drug effects</subject><subject>Orientation - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Rodents</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Space Perception - drug effects</subject><subject>Space Perception - physiology</subject><subject>Spatial Orientation (Perception)</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - physiology</subject><subject>Theta Rhythm</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp90Utv1DAQB3ALgei2IPEJUIRE4RIYP-I4x7I8ilTEocvZmjhO65LYwU4O_fY42uWhPfTi8Ug_jcb-E_KCwjsKvH6PAJRTrh6RDW14UwIo8ZhsoOZVWYMQJ-Q0pTsAECCqp-SENrk2gm1I3Iaxdd52xYchmJ_Y2SL0xbWNYQ7exhtnCvRd8W1JBqPzud1F9Gl0Kbngi48uxWWaUzHf2uLCzza6EIvdLQ44ZntpscsmWjOv-trdeByekSc9Dsk-P9Qz8uPzp932srz6_uXr9uKqRCHlXKKtBbJW2l4yha2UrEXZY9OqDpDyTkhsmVI99NLki6wN66gyjag7Y3hf8TPyZj93iuHXYtOs89bGDgN6G5aklaqg4krKLM8flLJRFQexwldH8C4sMb8pGypEw1gFDyEGXNWKMp7R2z0yMaQUba-n6EaM95qCXjPVfzLN9OVh3tKOtvsHDyFm8PoAMKc09Dkg49Jfx6CRQOXqyr3DCfWU7nOiszODTWaJ0fpZt95qypiW6_nftxz7Y_gbhOnFBw</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Sandoval, Kate</creator><creator>McDaniel, Kathrine M</creator><creator>Murawski, Nathen J</creator><creator>Doerr, Celeste E</creator><creator>Calton, Jeffrey L</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Combined Blockade of Serotonergic and Muscarinic Transmission Disrupts the Anterior Thalamic Head Direction Signal</title><author>Sandoval, Kate ; McDaniel, Kathrine M ; Murawski, Nathen J ; Doerr, Celeste E ; Calton, Jeffrey L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a466t-ae74a2b6ef628ab662ba6fa9b8d0a13d46ab288f0f6cb2867c2d18c947dcc3f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acetylcholine</topic><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>Animal</topic><topic>Animal Migratory Behavior</topic><topic>Animals</topic><topic>Antagonist drugs</topic><topic>Anterior Thalamic Nuclei - cytology</topic><topic>Anterior Thalamic Nuclei - drug effects</topic><topic>Anterior Thalamic Nuclei - physiology</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Cholinergic Agents - metabolism</topic><topic>Drug Combinations</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Head Movements - drug effects</topic><topic>Head Movements - physiology</topic><topic>Male</topic><topic>Methiothepin - pharmacology</topic><topic>Motor Activity - drug effects</topic><topic>Muscarinic Antagonists - pharmacology</topic><topic>N-Methylscopolamine - pharmacology</topic><topic>Neurons</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Neurosciences</topic><topic>Neurotransmitters</topic><topic>Orientation - drug effects</topic><topic>Orientation - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Rodents</topic><topic>Serotonin</topic><topic>Serotonin - metabolism</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Space Perception - drug effects</topic><topic>Space Perception - physiology</topic><topic>Spatial Orientation (Perception)</topic><topic>Synaptic Transmission - drug effects</topic><topic>Synaptic Transmission - physiology</topic><topic>Theta Rhythm</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sandoval, Kate</creatorcontrib><creatorcontrib>McDaniel, Kathrine M</creatorcontrib><creatorcontrib>Murawski, Nathen J</creatorcontrib><creatorcontrib>Doerr, Celeste E</creatorcontrib><creatorcontrib>Calton, Jeffrey L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PsycArticles (via ProQuest)</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sandoval, Kate</au><au>McDaniel, Kathrine M</au><au>Murawski, Nathen J</au><au>Doerr, Celeste E</au><au>Calton, Jeffrey L</au><au>Kelly, Anne E</au><au>Disterhoft, John F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined Blockade of Serotonergic and Muscarinic Transmission Disrupts the Anterior Thalamic Head Direction Signal</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>122</volume><issue>6</issue><spage>1226</spage><epage>1235</epage><pages>1226-1235</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>Head direction
(HD) cells have been speculated to be part of a network mediating navigational
behavior. Previous work has shown that combined administration of serotonergic
and muscarinic antagonists eliminates hippocampal theta activity and produces
navigational deficits more severe than blockade of either neurotransmitter
system alone. The authors sought to assess this effect on the directional
characteristics of HD cells. HD cells were recorded from the anterior dorsal
thalamus of Long-Evans rats before and after administration of the serotonergic
antagonist methiothepin, the muscarinic antagonist scopolamine, both drugs, or
saline. Combined drug administration produced HD cells with preferred directions
that drifted within recording sessions. In addition, cells showed shifts in the
preferred directions at the start of a session relative to the position of the
major landmarks, suggesting that combined drug administration led to deficits in
landmark control of the HD system. Single drug exposures to methiothepin or
scopolamine did not noticeably affect the directional characteristics of HD
cells. This finding that navigation-impairing drugs can disrupt the HD signal
provides further evidence that this network plays an important role in
navigational behavior.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>19045942</pmid><doi>10.1037/a0013138</doi><tpages>10</tpages></addata></record> |
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| ispartof | Behavioral neuroscience, 2008-12, Vol.122 (6), p.1226-1235 |
| issn | 0735-7044 1939-0084 |
| language | eng |
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| source | EBSCO_PsycARTICLES |
| subjects | Acetylcholine Action Potentials - drug effects Action Potentials - physiology Animal Animal Migratory Behavior Animals Antagonist drugs Anterior Thalamic Nuclei - cytology Anterior Thalamic Nuclei - drug effects Anterior Thalamic Nuclei - physiology Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Brain Cholinergic Agents - metabolism Drug Combinations Female Fundamental and applied biological sciences. Psychology Head Movements - drug effects Head Movements - physiology Male Methiothepin - pharmacology Motor Activity - drug effects Muscarinic Antagonists - pharmacology N-Methylscopolamine - pharmacology Neurons Neurons - drug effects Neurons - physiology Neurosciences Neurotransmitters Orientation - drug effects Orientation - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Long-Evans Rodents Serotonin Serotonin - metabolism Serotonin Antagonists - pharmacology Space Perception - drug effects Space Perception - physiology Spatial Orientation (Perception) Synaptic Transmission - drug effects Synaptic Transmission - physiology Theta Rhythm |
| title | Combined Blockade of Serotonergic and Muscarinic Transmission Disrupts the Anterior Thalamic Head Direction Signal |
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