Drug-loaded polyelectrolyte microcapsules for sustained targeting of cancer cells

In this review we will overview novel nanotechnological nanocarrier systems for cancer therapy focusing on recent development in polyelectrolyte capsules for targeted delivery of antineoplastic drugs against cancer cells. Biodegradable polyelectrolyte microcapsules (PMCs) are supramolecular assembli...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2011-08, Vol.63 (9), p.847-864
Main Authors: Vergaro, Viviana, Scarlino, Flavia, Bellomo, Claudia, Rinaldi, Rosaria, Vergara, Daniele, Maffia, Michele, Baldassarre, Francesca, Giannelli, Gianluigi, Zhang, Xingcai, Lvov, Yuri M., Leporatti, Stefano
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic drugs
Cancer therapy
Capsules - chemistry
Capsules - pharmacokinetics
Capsules - toxicity
Drug Compounding - methods
Drug delivery
Drug Delivery Systems - methods
Drug Screening Assays, Antitumor - methods
Electrolytes - chemistry
Humans
Layer-by-layer
Microcapsules
Nanocarriers
Nanotechnology
Nanotechnology - methods
Polyelectrolyte multilayers
Polymers - chemistry
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Summary:In this review we will overview novel nanotechnological nanocarrier systems for cancer therapy focusing on recent development in polyelectrolyte capsules for targeted delivery of antineoplastic drugs against cancer cells. Biodegradable polyelectrolyte microcapsules (PMCs) are supramolecular assemblies of particular interest for therapeutic purposes, as they can be enzymatically degraded into viable cells, under physiological conditions. Incorporation of small bioactive molecules into nano-to-microscale delivery systems may increase drug's bioavailability and therapeutic efficacy at single cell level giving desirable targeted therapy. Layer-by-layer (LbL) self-assembled PMCs are efficient microcarriers that maximize drug's exposure enhancing antitumor activity of neoplastic drug in cancer cells. They can be envisaged as novel multifunctional carriers for resistant or relapsed patients or for reducing dose escalation in clinical settings. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2011.05.007