One-Step Photochemical Synthesis of Permanent, Nonleaching, Ultrathin Antimicrobial Coatings for Textiles and Plastics

Antimicrobial copolymers of hydrophobic N-alkyl and benzophenone containing polyethylenimines were synthesized from commercially available linear poly(2-ethyl-2-oxazoline), and covalently attached to surfaces of synthetic polymers, cotton, and modified silicon oxide using mild photo-cross-linking. S...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2011-08, Vol.3 (8), p.2830-2837
Main Authors: Dhende, Vikram P, Samanta, Satyabrata, Jones, David M, Hardin, Ian R, Locklin, Jason
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Benzophenones - chemistry
Escherichia coli - drug effects
Photochemical Processes
Plastics - chemical synthesis
Plastics - chemistry
Plastics - pharmacology
Polyamines - chemistry
Polyethylenes - chemistry
Polypropylenes - chemistry
Polyvinyl Chloride - chemistry
Staphylococcus aureus - drug effects
Surface Properties
Textiles - toxicity
Ultraviolet Rays
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Summary:Antimicrobial copolymers of hydrophobic N-alkyl and benzophenone containing polyethylenimines were synthesized from commercially available linear poly(2-ethyl-2-oxazoline), and covalently attached to surfaces of synthetic polymers, cotton, and modified silicon oxide using mild photo-cross-linking. Specifically, these polymers were applied to polypropylene, poly(vinyl chloride), polyethylene, cotton, and alkyl-coated oxide surfaces using solution casting or spray coating and then covalently cross-linked rendering permanent, nonleaching antimicrobial surfaces. The photochemical grafting of pendant benzophenones allows immobilization to any surface that contains a C–H bond. Incubating the modified materials with either Staphylococcus aureus or Escherichia coli demonstrated that the modified surfaces had substantial antimicrobial capacity against both Gram-positive and Gram-negative bacteria (>98% microbial death).
ISSN:1944-8244
1944-8252
DOI:10.1021/am200324f