Importance of the Ankle-Brachial Pressure Index in the Diagnosis of Coronary Artery Disease in Women With Diabetes Without Anginal Pain

Background: Clinical symptoms of coronary artery disease (CAD) are often atypical in women, particularly in those with diabetes mellitus. Therefore, a simple diagnostic test to identify a high-risk subset of women with diabetes who are likely to have CAD is important. Methods and Results: A total of...

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Bibliographic Details
Published in:Circulation Journal 2011, Vol.75(9), pp.2206-2212
Main Authors: Igarashi, Yuko, Chikamori, Taishiro, Hida, Satoshi, Tanaka, Hirokazu, Shiba, Chie, Usui, Yasuhiro, Hatano, Tuguhisa, Yamashina, Akira
Format: Article
Language:English
Subjects:
Aged
Ankle Brachial Index
Ankle-brachial pressure index
Coronary artery disease
Coronary Artery Disease - diagnosis
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - physiopathology
Diabetes Complications - diagnostic imaging
Diabetes Complications - physiopathology
Diabetes mellitus
Female
Humans
Male
Middle Aged
Myocardial perfusion imaging
Radiography
Retrospective Studies
Sex Characteristics
Women
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Summary:Background: Clinical symptoms of coronary artery disease (CAD) are often atypical in women, particularly in those with diabetes mellitus. Therefore, a simple diagnostic test to identify a high-risk subset of women with diabetes who are likely to have CAD is important. Methods and Results: A total of 407 consecutive patients (319 men and 88 women, age range 68±11 years) with suspected CAD, who were not complaining of anginal pain, were evaluated. Among these patients, 170 had diabetes. Stress myocardial perfusion imaging and simultaneous brachial and ankle blood pressure measurements were performed to obtain the ischemic total perfusion deficit (TPD) and ankle-brachial pressure index (ABI), respectively. Ischemic TPD was not significantly different between men and women, whereas ischemic TPD was significantly greater in diabetic patients than in non-diabetic patients (6.9±7.7% vs. 4.9±6.1%; P=0.005). In diabetic patients, ischemic TPD was not significantly different between men and women. However, women with ABI10%, which is regarded as a scintigraphic indicator for coronary revascularization. (Circ J 2011; 75: 2206-2212)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-10-1287