Effects of taurine on glutathione peroxidase, glutathione reductase and reduced glutathione levels in rats

The aim of the present study is to investigate the effects of oral administration of taurine on endogenous glutathione peroxidase (GPx) and Glutathione Reductase (GR) activities and reduced glutathione (GSH) level in normal rats. Normal saline (Group I) or 5% taurine in normal saline was administere...

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Published in:Pakistan journal of biological sciences 2011-02, Vol.14 (3), p.219-225
Main Authors: Anand, P, Rajakumar, D, Jeraud, Mathew, Felix, A John William, Balasubramanian, T
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Antioxidants - administration & dosage
Antioxidants - adverse effects
Antioxidants - pharmacology
Dietary Supplements - adverse effects
Dose-Response Relationship, Drug
Female
Gastric Mucosa - metabolism
Glutathione - blood
Glutathione - metabolism
Glutathione Peroxidase - blood
Glutathione Peroxidase - metabolism
Glutathione Reductase - blood
Glutathione Reductase - metabolism
Heart - drug effects
Kidney - drug effects
Kidney - metabolism
Liver - drug effects
Liver - metabolism
Male
Myocardium - metabolism
Rats
Rats, Wistar
Stomach - drug effects
Taurine - administration & dosage
Taurine - adverse effects
Taurine - pharmacology
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Summary:The aim of the present study is to investigate the effects of oral administration of taurine on endogenous glutathione peroxidase (GPx) and Glutathione Reductase (GR) activities and reduced glutathione (GSH) level in normal rats. Normal saline (Group I) or 5% taurine in normal saline was administered in dose of 50 mg (Group II), 250 mg (Group III) or 500 mg kg(-1) of body weight (Group IV) through intragastric intubation for 60 days. GPx and GR enzyme activities and GSH and taurine levels were determined in liver, heart, stomach, kidney and plasma of normal Wistar rats. GPx activity showed an increase in liver, heart, stomach and plasma. GR activity increased in kidney and decreased in liver and plasma. GSH levels increased in liver, stomach and decreased in kidney. Liver showed an increase and heart, stomach and kidney a decrease in taurine level in taurine administered rats when compared to control rats. The results varied from organ to organ and the observed variations among organs might be related to their respective enzymatic, non-enzymatic antioxidant potential and its functions. From the present study it may be concluded that long term oral administration of taurine affects GPx, GR and GSH levels in normal rats.
ISSN:1028-8880
DOI:10.3923/pjbs.2011.219.225