Evaluation of osteoinduction properties of the demineralized bovine foetal growth plate powder as a new xenogenic biomaterial in rat

The aim of this study was evaluation of osteoinductive properties of demineralized bovine foetal growth plate in submuscular transplantation (ectopic osteoinduction) as a new xenogenic biomaterial in rat model. Demineralized bovine foetal growth plate was ectopically implanted in 18 male Sprague–Daw...

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Bibliographic Details
Published in:Research in veterinary science 2011-10, Vol.91 (2), p.306-310
Main Authors: Bigham, A.S., Shadkhast, M., Bigham Sadegh, A., Shafiei, Z., Lakzian, A., Khalegi, M.R.
Format: Article
Language:English
Subjects:
Animals
Bone Demineralization Technique
Bone Matrix - diagnostic imaging
Bone Matrix - pathology
Bone Matrix - transplantation
Bone Morphogenetic Proteins - analysis
Bone Regeneration
Bone Substitutes
Bone Transplantation - diagnostic imaging
Bone Transplantation - pathology
Bones
Bovine
Cartilage
Cattle
Demineralized fetus growth plate
Disease Models, Animal
Ectopic
Growth Plate - diagnostic imaging
Growth Plate - pathology
Growth Plate - transplantation
Gymnastics
Implants, Experimental
Male
Osteogenesis
Osteoinductionin rat
Radiography
Rats
Rats, Sprague-Dawley
Skeletal system
Transplantation, Heterologous
Veterinary medicine
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Summary:The aim of this study was evaluation of osteoinductive properties of demineralized bovine foetal growth plate in submuscular transplantation (ectopic osteoinduction) as a new xenogenic biomaterial in rat model. Demineralized bovine foetal growth plate was ectopically implanted in 18 male Sprague–Dawley rats. In 18 of the animals under aseptic conditions two submuscular pouches were created between external and internal oblique abdominal muscles in the two flanks: the right was left empty (sham) and the left was filled with 20 mg of demineralized bovine foetal growth plate powder. Radiographs were taken in 2, 4 and 6 weeks after the surgery, then six animals were pharmacologically euthanized after 2, 4 and 6 weeks for histopathological evaluation. Results showed: (1) osteoinductivity of xenogenic demineralized bovine foetal growth plate powder, and (2) earlier mineralization of ectopically implanted demineralized bovine foetal growth plate in the submuscular implanted area. Our results show that submuscular implantation of xenogenic demineralized bovine foetal growth plate has osteoinductive properties in a rat model.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2010.12.001