Suspected side effects of doxycycline use in dogs – a retrospective study of 386 cases

This study investigated doxycycline‐related side effects in a large population of dogs. Data from 386 dogs that had received doxycycline for the treatment of various infectious diseases were analysed retrospectively. Potential side effects that developed during treatment were documented, and correla...

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Bibliographic Details
Published in:Veterinary record 2011-08, Vol.169 (9), p.229-229
Main Authors: Schulz, B. S., Hupfauer, S., Ammer, H., Sauter‐Louis, C., Hartmann, K.
Format: Article
Language:English
Subjects:
Alanine Transaminase - metabolism
Alkaline Phosphatase - metabolism
Animals
Anorexia - chemically induced
Anorexia - enzymology
Anorexia - epidemiology
Anorexia - veterinary
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Diarrhea - chemically induced
Diarrhea - enzymology
Diarrhea - epidemiology
Diarrhea - veterinary
Dog Diseases - chemically induced
Dog Diseases - enzymology
Dog Diseases - epidemiology
Dogs
Dose-Response Relationship, Drug
Doxycycline - adverse effects
Doxycycline - therapeutic use
Female
Male
Retrospective Studies
Vomiting - chemically induced
Vomiting - enzymology
Vomiting - epidemiology
Vomiting - veterinary
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Summary:This study investigated doxycycline‐related side effects in a large population of dogs. Data from 386 dogs that had received doxycycline for the treatment of various infectious diseases were analysed retrospectively. Potential side effects that developed during treatment were documented, and correlations with signalment, dose, duration of treatment, frequency of application, doxycycline preparation and use of additional drugs were investigated. Vomiting was reported in 18.3 per cent of dogs, 7.0 per cent developed diarrhoea and 2.5 per cent developed anorexia. While being treated with doxycycline, 39.4 per cent of dogs showed an increase in alanine aminotransferase (ALT) activity and 36.4 per cent showed an increase in alkaline phosphatase (ALP) activity. There was a dose‐related risk of an increase in ALP activity (P=0.011, odds ratio [OR]=1.27, 95 per cent confidence interval [CI] 1.06 to 1.53), and older dogs treated with doxycycline were more likely to develop an increase in ALT activity (P=0.038, OR=1.23, 95 per cent CI 1.01 to 1.50) and vomiting (P=0.017, OR=1.11, 95 per cent CI 1.02 to 1.21).
ISSN:0042-4900
2042-7670
DOI:10.1136/vr.d4344