Primary malignant melanoma of the vagina with repeated local recurrences and brain metastasis

Abstract Malignant melanoma of the vagina, a very rare malignancy, has a notoriously aggressive behavior associated with a high risk of local recurrence and distant metastasis. At present, there are various treatment options for this disease but no standard guideline. We describe a case of a 54-year...

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Bibliographic Details
Published in:Journal of the Chinese Medical Association 2011-08, Vol.74 (8), p.376-379
Main Authors: Lin, Li-Te, Liu, Chung-Bin, Chen, San-Nung, Chiang, An-Jen, Liou, Wen-Shiung, Yu, Ken-Jen
Format: Article
Language:English
Subjects:
Aggressive behavior
Biochemotherapy
Brain
Brain metastasis
Brain Neoplasms - secondary
Chemotherapy
Female
Humans
Interferon alpha-2
Interferon-alpha - therapeutic use
Internal Medicine
Malignancy
Melanoma
Melanoma - pathology
Melanoma - secondary
Melanoma - therapy
Metastases
Middle Aged
Neoplasm Recurrence, Local - pathology
Radicals
Radiotherapy
Recombinant Proteins - therapeutic use
Risk factors
Surgery
Vagina
Vaginal Neoplasms - pathology
Vaginal Neoplasms - therapy
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Description
Summary:Abstract Malignant melanoma of the vagina, a very rare malignancy, has a notoriously aggressive behavior associated with a high risk of local recurrence and distant metastasis. At present, there are various treatment options for this disease but no standard guideline. We describe a case of a 54-year-old woman with a locally advanced melanoma of the vagina, who underwent radical surgery, biochemotherapy with interferon-α-2b, chemotherapy, radiotherapy, and repeat excision of local recurrent lesions and brain metastasis. In conclusion, malignant melanoma of the vagina has a high risk for local recurrence. Repeated local excision followed by biochemotherapy is a tolerable treatment.
ISSN:1726-4901
1728-7731
DOI:10.1016/j.jcma.2011.06.006