Association Between Tryptophan Hydroxylase-2 Gene and Late-Onset Depression

• Published in: The American journal of geriatric psychiatry 2011-09, Vol.19 (9), p.825-829
• Main Authors: de Araújo Pereira, Patricia, M.Sc, Romano-Silva, Marco Aurélio, M.D., Ph.D, Camargos Bicalho, Maria Aparecida, M.D., Ph.D, De Marco, Luiz, M.D., Ph.D, Correa, Humberto, M.D., Ph.D, de Campos, Simone Becho, M.Sc, de Moraes, Edgar Nunes, M.D., Ph.D, de Lima Torres, Karen Cecilia, Ph.D, de Souza, Bruno Rezende, Ph.D, de Miranda, Debora Marques, M.D., Ph.D
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Alleles; Case-Control Studies; Depression - diagnosis; Depression - genetics; Female; Genotype; Humans; Internal Medicine; late-onset depression (LOD); Male; Polymorphism, Single Nucleotide - genetics; single-nucleotide polymorphism (SNP); Tryptophan Hydroxylase - genetics; Tryptophan hydroxylase-2 (TPH2)
• ISSN: 1064-7481; 1545-7214
• DOI: 10.1097/JGP.0b013e31820eeb21

Objective The aim of this study was to examine the association between polymorphisms (SNP) in the tryptophan hydroxylase-2 (TPH2) gene and late-onset depression (LOD) in the Brazilian population. Methods We genotyped 8 tag SNPs in the TPH2 gene in 84 outpatients with LOD and 79 individuals belonging to the comparison group to investigate an association between the TPH2 gene and LOD. Results Our findings suggested an association between tag SNP rs4565946 heterozygous C/T (p = 0.034; χ2 = 6.7; df = 2) and decreased risk of LOD. The tag SNP rs 11179000 ancestral homozygous A/A (p = 0.025; χ2 = 7.3; df = 2) and increase risk of LOD and allelic association of ancestral allele A and increase risk of LOD was demonstrated (p = 0.005; χ2 = 7.8; df = 1). Conclusion We found the statistically significant association between two tag SNPs and LOD. Our results support the hypothesis that the TPH2 gene is associated with LOD.