The trophoblast binucleate cell is the source of maternal circulating C-type natriuretic peptide during ovine pregnancy

Abstract Maternal plasma concentrations of C-type natriuretic peptide (CNP) and a co-secreted bioinactive amino-terminal fragment (NTproCNP) are elevated during ovine pregnancy. Although the uteroplacental unit has been implicated as a likely source of CNP, the relative contributions of specific ute...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2011-09, Vol.32 (9), p.645-650
Main Authors: McNeill, B.A, Barrell, G.K, Wooding, F.B.P, Prickett, T.C.R, Espiner, E.A
Format: Article
Language:English
Subjects:
Animals
Binucleate cell
Biological and medical sciences
C-type natriuretic peptide
Embryology: invertebrates and vertebrates. Teratology
Female
Fetus
Fundamental and applied biological sciences. Psychology
Internal Medicine
Natriuretic Peptide, C-Type - blood
NTproCNP
Obstetrics and Gynecology
Placenta
Placenta - metabolism
Pregnancy
Pregnancy, Animal - physiology
Protein Precursors - blood
Sheep
Sheep, Domestic
Trophoblasts - cytology
Trophoblasts - metabolism
Uterus - metabolism
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Summary:Abstract Maternal plasma concentrations of C-type natriuretic peptide (CNP) and a co-secreted bioinactive amino-terminal fragment (NTproCNP) are elevated during ovine pregnancy. Although the uteroplacental unit has been implicated as a likely source of CNP, the relative contributions of specific uterine and placental tissues, and identity of the cellular site/s of production remain unknown. Therefore, we measured CNP and NTproCNP in intercaruncular uterine tissue and maternal (caruncle) and fetal (cotyledon) placental tissues throughout gestation. Concentrations of CNP forms in placental tissues greatly exceeded those in intercaruncular uterine tissue throughout pregnancy ( P  
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2011.06.001