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Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents
Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25–12.5μg/mL against Mycobacterium tuberculosis H37Rv.
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Published in: | Carbohydrate research 2011-09, Vol.346 (13), p.1760-1766 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25–12.5μg/mL against Mycobacterium tuberculosis H37Rv. |
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ISSN: | 0008-6215 1873-426X |
DOI: | 10.1016/j.carres.2011.05.034 |