Loading…
Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents
Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25–12.5μg/mL against Mycobacterium tuberculosis H37Rv.
Saved in:
| Published in: | Carbohydrate research 2011-09, Vol.346 (13), p.1760-1766 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c385t-e06ca5dba79225b63072c07bb04dea32227699f81d7a02e55d37cb446ab2154e3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c385t-e06ca5dba79225b63072c07bb04dea32227699f81d7a02e55d37cb446ab2154e3 |
| container_end_page | 1766 |
| container_issue | 13 |
| container_start_page | 1760 |
| container_title | Carbohydrate research |
| container_volume | 346 |
| creator | Mugunthan, G. Sriram, Dharmarajan Yogeeswari, Perumal Ravindranathan Kartha, K.P. |
| description | Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25–12.5μg/mL against Mycobacterium tuberculosis H37Rv. |
| doi_str_mv | 10.1016/j.carres.2011.05.034 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_886597949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0008621511003077</els_id><sourcerecordid>886597949</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-e06ca5dba79225b63072c07bb04dea32227699f81d7a02e55d37cb446ab2154e3</originalsourceid><addsrcrecordid>eNp9kcFu3CAQhlHUKtmmfYOq9a0nO4AN2JdKVZQ2lSL1kEbqDY1hvGFlmw3glTZPX1ZOe8xpBPP9A3wQ8pHRilEmr3aVgRAwVpwyVlFR0bo5IxvWqrpsuPzzhmwopW0pORMX5F2Mu7ykUslzcsGZYk0nug15uj_O6RGjiwXMtuidH_3WGRgLPMC4QHJ-LvxQxGULobQY3AFtYR5dyMjsUvBuchae_Yh5Qiz2PuGcXG5CLtPR-B5MyrHTzja34nvydoAx4oeXekkevt_8vr4t7379-Hn97a40dStSiVQaELYH1XEuellTxQ1VfU8bi1BzzpXsuqFlVgHlKIStlembRkKfH9xgfUm-rHP3wT8tGJOeXDQ4jjCjX6JuWyk61TVdJpuVNMHHGHDQ--AmCEfNqD651ju9utYn15oKnV3n2KeXA5Z-Qvs_9E9uBj6vwABewza4qB_u8wR5-gjK6joTX1cCs4iDw6CjcTgbtC6gSdp69_od_gLYTp3C</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>886597949</pqid></control><display><type>article</type><title>Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents</title><source>ScienceDirect Journals</source><creator>Mugunthan, G. ; Sriram, Dharmarajan ; Yogeeswari, Perumal ; Ravindranathan Kartha, K.P.</creator><creatorcontrib>Mugunthan, G. ; Sriram, Dharmarajan ; Yogeeswari, Perumal ; Ravindranathan Kartha, K.P.</creatorcontrib><description>Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25–12.5μg/mL against Mycobacterium tuberculosis H37Rv.</description><identifier>ISSN: 0008-6215</identifier><identifier>EISSN: 1873-426X</identifier><identifier>DOI: 10.1016/j.carres.2011.05.034</identifier><identifier>PMID: 21714959</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; antibacterial properties ; antibiotics ; Antimycobacterial agents ; Antitubercular Agents - chemical synthesis ; Antitubercular Agents - chemistry ; Antitubercular Agents - pharmacology ; Carbohydrates ; Chiral pool ; Microbial Sensitivity Tests ; Molecular Structure ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - drug effects ; Nitroimidazoles ; Nitroimidazoles - chemical synthesis ; Nitroimidazoles - chemistry ; Nitroimidazoles - pharmacology ; sugars</subject><ispartof>Carbohydrate research, 2011-09, Vol.346 (13), p.1760-1766</ispartof><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-e06ca5dba79225b63072c07bb04dea32227699f81d7a02e55d37cb446ab2154e3</citedby><cites>FETCH-LOGICAL-c385t-e06ca5dba79225b63072c07bb04dea32227699f81d7a02e55d37cb446ab2154e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21714959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mugunthan, G.</creatorcontrib><creatorcontrib>Sriram, Dharmarajan</creatorcontrib><creatorcontrib>Yogeeswari, Perumal</creatorcontrib><creatorcontrib>Ravindranathan Kartha, K.P.</creatorcontrib><title>Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents</title><title>Carbohydrate research</title><addtitle>Carbohydr Res</addtitle><description>Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25–12.5μg/mL against Mycobacterium tuberculosis H37Rv.</description><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antibacterial properties</subject><subject>antibiotics</subject><subject>Antimycobacterial agents</subject><subject>Antitubercular Agents - chemical synthesis</subject><subject>Antitubercular Agents - chemistry</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Carbohydrates</subject><subject>Chiral pool</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Structure</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Nitroimidazoles</subject><subject>Nitroimidazoles - chemical synthesis</subject><subject>Nitroimidazoles - chemistry</subject><subject>Nitroimidazoles - pharmacology</subject><subject>sugars</subject><issn>0008-6215</issn><issn>1873-426X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu3CAQhlHUKtmmfYOq9a0nO4AN2JdKVZQ2lSL1kEbqDY1hvGFlmw3glTZPX1ZOe8xpBPP9A3wQ8pHRilEmr3aVgRAwVpwyVlFR0bo5IxvWqrpsuPzzhmwopW0pORMX5F2Mu7ykUslzcsGZYk0nug15uj_O6RGjiwXMtuidH_3WGRgLPMC4QHJ-LvxQxGULobQY3AFtYR5dyMjsUvBuchae_Yh5Qiz2PuGcXG5CLtPR-B5MyrHTzja34nvydoAx4oeXekkevt_8vr4t7379-Hn97a40dStSiVQaELYH1XEuellTxQ1VfU8bi1BzzpXsuqFlVgHlKIStlembRkKfH9xgfUm-rHP3wT8tGJOeXDQ4jjCjX6JuWyk61TVdJpuVNMHHGHDQ--AmCEfNqD651ju9utYn15oKnV3n2KeXA5Z-Qvs_9E9uBj6vwABewza4qB_u8wR5-gjK6joTX1cCs4iDw6CjcTgbtC6gSdp69_od_gLYTp3C</recordid><startdate>20110927</startdate><enddate>20110927</enddate><creator>Mugunthan, G.</creator><creator>Sriram, Dharmarajan</creator><creator>Yogeeswari, Perumal</creator><creator>Ravindranathan Kartha, K.P.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110927</creationdate><title>Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents</title><author>Mugunthan, G. ; Sriram, Dharmarajan ; Yogeeswari, Perumal ; Ravindranathan Kartha, K.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-e06ca5dba79225b63072c07bb04dea32227699f81d7a02e55d37cb446ab2154e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antibacterial properties</topic><topic>antibiotics</topic><topic>Antimycobacterial agents</topic><topic>Antitubercular Agents - chemical synthesis</topic><topic>Antitubercular Agents - chemistry</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Carbohydrates</topic><topic>Chiral pool</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Structure</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Nitroimidazoles</topic><topic>Nitroimidazoles - chemical synthesis</topic><topic>Nitroimidazoles - chemistry</topic><topic>Nitroimidazoles - pharmacology</topic><topic>sugars</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mugunthan, G.</creatorcontrib><creatorcontrib>Sriram, Dharmarajan</creatorcontrib><creatorcontrib>Yogeeswari, Perumal</creatorcontrib><creatorcontrib>Ravindranathan Kartha, K.P.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mugunthan, G.</au><au>Sriram, Dharmarajan</au><au>Yogeeswari, Perumal</au><au>Ravindranathan Kartha, K.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents</atitle><jtitle>Carbohydrate research</jtitle><addtitle>Carbohydr Res</addtitle><date>2011-09-27</date><risdate>2011</risdate><volume>346</volume><issue>13</issue><spage>1760</spage><epage>1766</epage><pages>1760-1766</pages><issn>0008-6215</issn><eissn>1873-426X</eissn><abstract>Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25–12.5μg/mL against Mycobacterium tuberculosis H37Rv.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>21714959</pmid><doi>10.1016/j.carres.2011.05.034</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-6215 |
| ispartof | Carbohydrate research, 2011-09, Vol.346 (13), p.1760-1766 |
| issn | 0008-6215 1873-426X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_886597949 |
| source | ScienceDirect Journals |
| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial properties antibiotics Antimycobacterial agents Antitubercular Agents - chemical synthesis Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Carbohydrates Chiral pool Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Nitroimidazoles Nitroimidazoles - chemical synthesis Nitroimidazoles - chemistry Nitroimidazoles - pharmacology sugars |
| title | Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T03%3A59%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20and%20biological%20evaluation%20of%20sugar-derived%20chiral%20nitroimidazoles%20as%20potential%20antimycobacterial%20agents&rft.jtitle=Carbohydrate%20research&rft.au=Mugunthan,%20G.&rft.date=2011-09-27&rft.volume=346&rft.issue=13&rft.spage=1760&rft.epage=1766&rft.pages=1760-1766&rft.issn=0008-6215&rft.eissn=1873-426X&rft_id=info:doi/10.1016/j.carres.2011.05.034&rft_dat=%3Cproquest_cross%3E886597949%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c385t-e06ca5dba79225b63072c07bb04dea32227699f81d7a02e55d37cb446ab2154e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=886597949&rft_id=info:pmid/21714959&rfr_iscdi=true |