A novel DTPA cross-linking of hyaluronic acid and metal complexation thereof

Macromolecular conjugates of a natural polysaccharide, hyaluronic acid, with diethylenetriaminepentaacetic acid (DTPA)—metal complexes were synthesized and characterized by FTIR, NMR, SEC-MALLS and ICP analysis. Several parameters of the cross-linking reaction as molecular weight of starting HA, tem...

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Bibliographic Details
Published in:Carbohydrate research 2011-09, Vol.346 (13), p.1909-1915
Main Authors: Buffa, Radovan, Běťák, Jiří, Kettou, Sofiane, Hermannová, Martina, Pospíšilová, Lucie, Velebný, Vladimír
Format: Article
Language:English
Subjects:
catalysts
Complex
Cross-linking
crosslinking
DTPA
Fourier transform infrared spectroscopy
Hyaluronic acid
Hyaluronic Acid - chemistry
Magnetic Resonance Spectroscopy
Metal
Molecular Structure
molecular weight
nuclear magnetic resonance spectroscopy
Pentetic Acid - chemistry
rheological properties
Spectroscopy, Fourier Transform Infrared
Temperature
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Summary:Macromolecular conjugates of a natural polysaccharide, hyaluronic acid, with diethylenetriaminepentaacetic acid (DTPA)—metal complexes were synthesized and characterized by FTIR, NMR, SEC-MALLS and ICP analysis. Several parameters of the cross-linking reaction as molecular weight of starting HA, temperature, equivalent of DTPA bis-anhydride, concentration of HA, presence of transacylation catalyst DMAP and reaction time were studied. The mechanism for the reaction was suggested and relationship between the molecular weight assigned by SEC-MALLS, reaction parameters and rheological properties of the final cross-linked products were investigated.
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2011.04.015