Salinomycin inhibits osteosarcoma by targeting its tumor stem cells

Highlights ► We have utilized three different methods to enrich TSCs in osteosarcoma. ► Salinomycin could selectively target TSCs in osteosarcoma both in vitro and in vivo . ► Wnt/β-catenin signaling pathway may be involved in this inhibition of salinomycin. ► Salinomycin is an effective inhibitor o...

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Bibliographic Details
Published in:Cancer letters 2011-12, Vol.311 (1), p.113-121
Main Authors: Tang, Qing-Lian, Zhao, Zhi-Qiang, Li, Jin-chun, Liang, Yi, Yin, Jun-Qiang, Zou, Chang-Ye, Xie, Xian-Biao, Zeng, Yi-Xin, Shen, Jing-Nan, Kang, Tiebang, Wang, Jin
Format: Article
Language:English
Subjects:
Adolescence
Bone marrow
Bone Neoplasms - drug therapy
Bone Neoplasms - metabolism
Bone Neoplasms - pathology
Bone tumors
Cell Line, Tumor
Chemotherapy
Children
Cloning
Down-Regulation - drug effects
Drug Resistance, Neoplasm
Experiments
Hematology, Oncology and Palliative Medicine
Humans
Immunohistochemistry
Metastases
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Oct-4 protein
Octamer Transcription Factor-3 - biosynthesis
Osteosarcoma
Osteosarcoma - drug therapy
Osteosarcoma - metabolism
Osteosarcoma - pathology
Osteosarcoma cells
Overexpression
Prognosis
Proteins
Pyrans - pharmacology
Salinomycin
Side effects
Signal transduction
SOXB1 Transcription Factors - biosynthesis
Stem cells
Surgery
Tumor stem cell
Wnt protein
Wnt Signaling Pathway - drug effects
Wnt/β-catenin
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Summary:Highlights ► We have utilized three different methods to enrich TSCs in osteosarcoma. ► Salinomycin could selectively target TSCs in osteosarcoma both in vitro and in vivo . ► Wnt/β-catenin signaling pathway may be involved in this inhibition of salinomycin. ► Salinomycin is an effective inhibitor of osteosarcoma stem cells.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2011.07.016