Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer

• Published in: Histopathology 2011-08, Vol.59 (2), p.198-206
• Main Authors: Xing, Xiao-Fang, Li, Hong, Zhong, Xi-Yao, Zhang, Lian-Hai, Wang, Xiao-Hong, Liu, Yi-Qiang, Jia, Shu-Qin, Shi, Tao, Niu, Zhao-Jian, Peng, Yong, Du, Hong, Zhang, Gui-Guo, Hu, Ying, Lu, Ai-Ping, Li, Ji-You, Chen, She, Ji, Jia-Fu
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - enzymology; Adenocarcinoma - mortality; Adenocarcinoma - secondary; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers, Tumor - metabolism; China - epidemiology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Group II Phospholipases A2 - metabolism; Humans; intestinal metaplasia; Investigative techniques, diagnostic techniques (general aspects); Lymphatic Metastasis; Male; Medical sciences; Middle Aged; Muramidase - metabolism; Neoplasm Invasiveness; Other diseases. Semiology; Paneth Cells - enzymology; Paneth Cells - pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; phospholipase A2 group IIA; prognosis; stomach neoplasms; Stomach Neoplasms - enzymology; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Survival Rate; Tumors
• ISSN: 0309-0167; 1365-2559
• DOI: 10.1111/j.1365-2559.2011.03913.x

Xing X‐F, Li H, Zhong X‐Y, Zhang L‐H, Wang X‐H, Liu Y‐Q, Jia S‐Q, Shi T, Niu Z‐J, Peng Y, Du H, Zhang G‐G, Hu Y, Lu A‐P, Li J‐Y, Chen S & Ji J‐F 
(2011) Histopathology59, 198–206 Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer Aims:  The secreted phospholipase A2 type IIA (PLA2G2A) gene has been identified as a modifier of intestinal adenoma multiplicity in ApcMin/+ mice. The aim of the present study was to analyse the clinical significance of PLA2G2A expression in human gastric cancer. Methods and results:  Using immunohistochemistry, cytoplasmic immunoreactivity of PLA2G2A was observed in 27% (40 of 149) of gastric cancer tissues compared with negative staining in normal mucosa. The PLA2G2A expression rate in well‐differentiated carcinoma was elevated significantly compared with that in poorly differentiated carcinoma (46% versus 19%, P = 0.001). Statistical analysis also revealed that PLA2G2A expression correlated negatively with depth of mural invasion, lymph node metastasis and tumour–node–metastasis (TNM) stage (P