Anabolic Status and Functional Impairment in Men With Mild Chronic Heart Failure

The purpose of this study was to establish the role of hormonal anabolic deficiencies in exercise intolerance in patients with chronic heart failure One hundred four consecutive men (mean age 53.1 ± 10.6 years) with established diagnoses of chronic heart failure were included. At enrollment, blood s...

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Bibliographic Details
Published in:The American journal of cardiology 2011-09, Vol.108 (6), p.862-866
Main Authors: Pastor-Pérez, Francisco J., MD, Manzano-Fernández, Sergio, MD, PhD, Garrido Bravo, Iris P., MD, Nicolás, Francisco, MD, Tornel, Pedro L., MD, PhD, Lax, Antonio, PhD, de la Morena, Gonzalo, MD, PhD, Valdés, Mariano, MD, PhD, Pascual-Figal, Domingo A., MD, PhD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
Chronic Disease
Dehydroepiandrosterone - deficiency
Echocardiography
Electrocardiography
Exercise
Exercise Test
Exercise Tolerance
Heart
Heart failure
Heart Failure - metabolism
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hormones
Humans
Insulin-Like Growth Factor I - deficiency
Male
Medical sciences
Mens health
Middle Aged
Multivariate Analysis
Oxygen Consumption
Predictive Value of Tests
Prognosis
Respiratory Function Tests
Testosterone - deficiency
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Summary:The purpose of this study was to establish the role of hormonal anabolic deficiencies in exercise intolerance in patients with chronic heart failure One hundred four consecutive men (mean age 53.1 ± 10.6 years) with established diagnoses of chronic heart failure were included. At enrollment, blood samples were taken, and echocardiography and cardiopulmonary exercise testing were carried out. Exercise capacity was expressed as peak oxygen consumption (V o2 ), predicted peak V o2 , and the ventilatory response to exercise (VE/V co2 ) slope. The mean left ventricular ejection fraction was 29.7 ± 11.9%, and most patients (86%) were in New York Heart Association class I or II, with a mean peak V o2 of 18 ml/min/kg. According to the age-adjusted reference values, hormonal deficiencies were present in 29% for total testosterone, 39% for estimated free testosterone, 34% for insulin-like growth factor–1, and 61% for dehydroepiandrosterone sulfate. Dehydroepiandrosterone sulfate showed a significant correlation with peak V o2 (r = 0.29, p = 0.007), predicted peak V o2 (r = 0.28, p = 0.006), and VE/V co2 slope (r = −0.39, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2011.05.016