APOE ε4 is associated with higher vitamin D levels in targeted replacement mice and humans

ABSTRACT The allele ε4 of apolipoprotein E (APOE), which is a key regulator of lipid metabolism, represents a risk factor for cardiovascular diseases and Alzheimer's disease. Despite its adverse effects, the allele is common and shows a nonrandom global distribution that is thought to be the re...

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Bibliographic Details
Published in:The FASEB journal 2011-09, Vol.25 (9), p.3262-3270
Main Authors: Huebbe, Patricia, Nebel, Almut, Siegert, Sabine, Moehring, Jennifer, Boesch‐Saadatmandi, Christine, Most, Erika, Pallauf, Josef, Egert, Sarah, Müller, Manfred James, Schreiber, Stefan, Nöthlings, Ute, Rimbach, Gerald
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Animals
apolipoprotein E
Apolipoprotein E4 - genetics
Apolipoprotein E4 - metabolism
Calcium - metabolism
evolutionary advantage
Female
Genotype
global allele distribution
Homeostasis
Humans
Male
Mice
Mice, Transgenic
Middle Aged
Vitamin D - blood
ε4 allele
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Summary:ABSTRACT The allele ε4 of apolipoprotein E (APOE), which is a key regulator of lipid metabolism, represents a risk factor for cardiovascular diseases and Alzheimer's disease. Despite its adverse effects, the allele is common and shows a nonrandom global distribution that is thought to be the result of evolutionary adaptation. One hypothesis proposes that the APOE ε4 allele protects against vitamin D deficiency. Here we present, for the first time, experimental and epidemiological evidence that the APOE ε4 allele is indeed associated with higher serum vitamin D [25(OH)D] levels. In APOE4 targeted replacement mice, significantly higher 25(OH)D levels were found compared with those in APOE2 and APOE3 mice (70.9 vs. 41.8 and 27.8 nM, P
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.11-180935