Inhibitory effect of carboxymethylpachymaran on cyclophosphamide-induced oxidative stress in mice

The aim of the present study was to investigate the immunomodulatory effect and antioxidant activity of carboxymethylpachymaran on cyclophosphamide-induced immunosuppression in mice in vivo. The results showed that carboxymethylpachymaran could be used to overcome the cyclophosphamide-induced immuno...

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Bibliographic Details
Published in:International journal of biological macromolecules 2011-11, Vol.49 (4), p.801-805
Main Authors: Wei, Xiao-Jie, Hu, Ting-Jun, Chen, Jiong-Ran, Wei, Ying-Yi
Format: Article
Language:English
Subjects:
Animals
antioxidant activity
Antioxidants - metabolism
Carboxymethylpachymaran
catalase
Catalase - metabolism
Cyclophosphamide
Cyclophosphamide - antagonists & inhibitors
Cyclophosphamide - toxicity
Female
Glucans - pharmacology
Immunity
lysozyme
Male
malondialdehyde
Malondialdehyde - metabolism
Mice
Mice, Inbred BALB C
Muramidase - metabolism
Oxidative stress
Oxidative Stress - drug effects
spleen
Spleen - drug effects
Spleen - enzymology
Spleen - pathology
Superoxide Dismutase - metabolism
thymus gland
Thymus Gland - drug effects
Thymus Gland - pathology
xanthine oxidase
Xanthine Oxidase - metabolism
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Summary:The aim of the present study was to investigate the immunomodulatory effect and antioxidant activity of carboxymethylpachymaran on cyclophosphamide-induced immunosuppression in mice in vivo. The results showed that carboxymethylpachymaran could be used to overcome the cyclophosphamide-induced immunosuppression in mice. Moreover, it significantly increased the thymus and spleen indices, lysozyme, catalase and superoxidase dismutase activities, and total antioxidant capacity. In contrast, it decreased xanthine oxidase activity and malondialdehyde levels. The results indicated that carboxymethylpachymaran might play an important role in the prevention of oxidative damage in the immunological system.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2011.07.017