The analysis of substituted cathinones. Part 1: Chemical analysis of 2-, 3- and 4-methylmethcathinone

Abstract The ring substituted methyl isomers of methcathinone, 2-, 3- and 4-methylmethcathinone were analysed. The 2- and 3-isomers were synthesized. The 4-methylmethcathinone isomer is also known as mephedrone and has been widely studied. We present GCMS, NMR and IR data for the three isomers. We s...

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Bibliographic Details
Published in:Forensic science international 2011-10, Vol.212 (1), p.6-12
Main Authors: Power, John D, McGlynn, Peggy, Clarke, Karen, McDermott, Seán D, Kavanagh, Pierce, O’Brien, John
Format: Article
Language:English
Subjects:
Analysis
Analytical chemistry
Biological and medical sciences
Chemical
Chemical analysis
Drug
Forensic
Forensic medicine
Forensic science
Forensic sciences
Forensic Toxicology - methods
Gas Chromatography-Mass Spectrometry - methods
General aspects
Humans
Infrared radiation
Investigative techniques, diagnostic techniques (general aspects)
Isomerism
Isomers
Magnetic Resonance Spectroscopy - methods
Medical sciences
Mephedrone
Methamphetamine - analogs & derivatives
Methamphetamine - analysis
Methamphetamine - chemistry
NMR
Nuclear magnetic resonance
Pathology
Public health. Hygiene
Public health. Hygiene-occupational medicine
Sampling Studies
Seizing
Sensitivity and Specificity
Spectra
Stimulants
Street Drugs - analysis
Street Drugs - chemistry
Studies
Synthesis
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Summary:Abstract The ring substituted methyl isomers of methcathinone, 2-, 3- and 4-methylmethcathinone were analysed. The 2- and 3-isomers were synthesized. The 4-methylmethcathinone isomer is also known as mephedrone and has been widely studied. We present GCMS, NMR and IR data for the three isomers. We show that the three isomers can be separated by GCMS and that the IR spectra for the three compounds can be used to distinguish between them. A seized sample was analysed and it was found to contain 4-methylmethcathinone and benzocaine.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2011.04.020