Prognostic implication of ezrin expression in esophageal squamous cell carcinoma

Background and Objectives Ezrin, a member of the ezrin–radixin–moesin family, was implicated in tumor progression, metastatic dissemination, and adverse outcomes in several cancer types, including esophageal squamous cell carcinoma (ESCC). The purpose of this study was to explore the clinical signif...

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Published in:Journal of surgical oncology 2011-10, Vol.104 (5), p.538-543
Main Authors: Xie, Jian-Jun, Xu, Li-Yan, Wu, Zhi-Yong, Zhao, Qing, Xu, Xiu-E, Wu, Jian-Yi, Huang, Qiao, Li, En-Min
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
biomarker
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - secondary
Cytoskeletal Proteins - metabolism
ESCC
Esophageal Neoplasms - metabolism
Esophageal Neoplasms - pathology
ezrin
Female
Follow-Up Studies
Humans
Immunoenzyme Techniques
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Recurrence, Local - metabolism
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Prognosis
prognostic factor
Retrospective Studies
Survival Rate
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Summary:Background and Objectives Ezrin, a member of the ezrin–radixin–moesin family, was implicated in tumor progression, metastatic dissemination, and adverse outcomes in several cancer types, including esophageal squamous cell carcinoma (ESCC). The purpose of this study was to explore the clinical significance of ezrin expression in ESCC. Methods Ezrin expression was detected on tissue microarrays of ESCC samples in 307 cases using immunohistochemical staining. Survival analysis was assessed by the Kaplan–Meier analysis. Relative risk was evaluated by the multivariate Cox proportional hazards model. Results The staining pattern of ezrin was heterogeneous and varied from negative/weakly to intense expression in a cytoplasmic distribution. Kaplan–Meier survival analysis showed that ezrin expression was related to poor overall survival of ESCC patients (P = 0.023). Further analysis revealed that ezrin expression was associated with the survival in the cases of stage III/IV (P = 0.002); but did not influence the survival in the patients of stage I/II. Multivariate Cox analysis demonstrated that ezrin was an independent factor in prognosis of ESCC (P = 0.011). Conclusions Ezrin might be a new molecular marker to predict the prognosis of ESCC patients. J. Surg. Oncol. 2011; 104:538–543. © 2011 Wiley‐Liss, Inc.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.21909