Tumefactive Demyelination— An Unusual Neurological Presentation of HIV

We describe 3 individuals infected with human immunodeficiency virus with unusual focal brain syndromes; magnetic resonance imaging revealed “open-ring” pattern space occupying lesions. After deterioration while the patientswere receiving anti-Toxoplasma therapy, brain biopsy was performed, which re...

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Bibliographic Details
Published in:Clinical infectious diseases 2010-11, Vol.51 (10), p.1217-1220
Main Authors: Uriel, Alison, Stow, Rachael, Johnson, Leann, Varma, Anoop, du Plessis, Daniel, Gray, Francois, Herwadkar, Amit, Holland, Jeremy, Lewthwaite, Penny, Wilkins, Ed
Format: Article
Language:English
Subjects:
Adult
Anti-Retroviral Agents - therapeutic use
Biological and medical sciences
Brain
Brain Diseases - drug therapy
Brain Diseases - virology
Brain Edema - drug therapy
Brain Edema - virology
Clinical medicine
Demyelinating diseases
Demyelinating Diseases - drug therapy
Demyelinating Diseases - virology
Female
HIV
HIV infections
HIV Infections - complications
HIV Infections - drug therapy
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Imaging
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Infectious diseases
Lesions
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Multiple sclerosis
Neuroimaging
Neurology
NMR
Nuclear magnetic resonance
Steroids
Steroids - therapeutic use
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Description
Summary:We describe 3 individuals infected with human immunodeficiency virus with unusual focal brain syndromes; magnetic resonance imaging revealed “open-ring” pattern space occupying lesions. After deterioration while the patientswere receiving anti-Toxoplasma therapy, brain biopsy was performed, which revealed aggressive demyelination consistent with tumefactive demyelination. Treatment with high-dose steroids resulted in complete recovery in all cases.
ISSN:1058-4838
1537-6591
DOI:10.1086/656812