Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population

Objective: Current guidelines on stroke prevention have recommendations on desirable cholesterol levels, but not on nonfasting triglycerides. We compared stepwise increasing levels of nonfasting triglycerides and cholesterol for their association with risk of ischemic stroke in the general populatio...

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Bibliographic Details
Published in:Annals of neurology 2011-04, Vol.69 (4), p.628-634
Main Authors: Varbo, Anette, Nordestgaard, Børge G., Tybjærg-Hansen, Anne, Schnohr, Peter, Jensen, Gorm B., Benn, Marianne
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers - blood
Brain Ischemia - blood
Brain Ischemia - complications
Cerebral Infarction - complications
Cholesterol
Cholesterol, LDL - blood
Confidence intervals
Confounding Factors (Epidemiology)
Cross-Sectional Studies
Denmark - epidemiology
Drug therapy
Female
Follow-Up Studies
Humans
Male
Medical sciences
Middle Aged
Multivariate Analysis
Neurology
Odds Ratio
Prospective Studies
Registries
Risk Assessment
Risk Factors
Stroke
Stroke - blood
Stroke - epidemiology
Stroke - etiology
Triglycerides
Triglycerides - blood
Vascular diseases and vascular malformations of the nervous system
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Summary:Objective: Current guidelines on stroke prevention have recommendations on desirable cholesterol levels, but not on nonfasting triglycerides. We compared stepwise increasing levels of nonfasting triglycerides and cholesterol for their association with risk of ischemic stroke in the general population. Methods: A total of 7,579 women and 6,372 men from the Copenhagen City Heart Study with measurements of nonfasting triglycerides and cholesterol at baseline in 1976–1978 were followed for up to 33 years; of these, 837 women and 837 men developed ischemic stroke during follow‐up, which was 100% complete. Results: The fluctuation of nonfasting triglycerides and cholesterol over 15 years was similar. In both women and men, stepwise increasing levels of nonfasting triglycerides were associated with increased risk of ischemic stroke. Compared to women with triglycerides
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.22384