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Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population
Objective: Current guidelines on stroke prevention have recommendations on desirable cholesterol levels, but not on nonfasting triglycerides. We compared stepwise increasing levels of nonfasting triglycerides and cholesterol for their association with risk of ischemic stroke in the general populatio...
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| Published in: | Annals of neurology 2011-04, Vol.69 (4), p.628-634 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4524-545dc56a51cae424829a38631cae785b7df8f4c26885f65bf0fed459f86a231f3 |
| container_end_page | 634 |
| container_issue | 4 |
| container_start_page | 628 |
| container_title | Annals of neurology |
| container_volume | 69 |
| creator | Varbo, Anette Nordestgaard, Børge G. Tybjærg-Hansen, Anne Schnohr, Peter Jensen, Gorm B. Benn, Marianne |
| description | Objective:
Current guidelines on stroke prevention have recommendations on desirable cholesterol levels, but not on nonfasting triglycerides. We compared stepwise increasing levels of nonfasting triglycerides and cholesterol for their association with risk of ischemic stroke in the general population.
Methods:
A total of 7,579 women and 6,372 men from the Copenhagen City Heart Study with measurements of nonfasting triglycerides and cholesterol at baseline in 1976–1978 were followed for up to 33 years; of these, 837 women and 837 men developed ischemic stroke during follow‐up, which was 100% complete.
Results:
The fluctuation of nonfasting triglycerides and cholesterol over 15 years was similar. In both women and men, stepwise increasing levels of nonfasting triglycerides were associated with increased risk of ischemic stroke. Compared to women with triglycerides |
| doi_str_mv | 10.1002/ana.22384 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_888099067</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3276260001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4524-545dc56a51cae424829a38631cae785b7df8f4c26885f65bf0fed459f86a231f3</originalsourceid><addsrcrecordid>eNqF0d9rUzEUB_AgiqvTB_8BCYiIsLvl9819LNN1yqgvk4EvIc1N2mxp0iX3ov3vTW03QRCfQuBzTk7OF4DXGJ1ihMiZjvqUECrZEzDBnOJGEtY9BRNEBWs4puwIvCjlFiHUCYyegyOCKW0F4hNwPU_R6TL4uIRD9suwNTb73pYTaFYp2DLYnMIJ1LGHvpiVXXsDy5DTnYU-wmFl4dJGm3WAm7QZgx58ii_BM6dDsa8O5zH4dvHp-vyyufo6-3w-vWoM46ROxnhvuNAcG20ZYZJ0mkpBd9dW8kXbO-mYIUJK7gRfOORsz3jnpNCEYkePwft9301O92OdVa3rjDYEHW0ai5JSoq5Dov2_FHUfQhJa5du_5G0ac6zfUJhjwQSWdNfvw16ZnErJ1qlN9mudtwojtctE1UzU70yqfXPoOC7Wtn-UDyFU8O4AdDE6uKyj8eWPY5i1FVZ3tnc_fLDbf7-opvPpw9PNvsLXHH8-Vuh8p-pSWq5u5jP15fvNRzy7lOqC_gJKuLCg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1516461837</pqid></control><display><type>article</type><title>Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population</title><source>Wiley</source><creator>Varbo, Anette ; Nordestgaard, Børge G. ; Tybjærg-Hansen, Anne ; Schnohr, Peter ; Jensen, Gorm B. ; Benn, Marianne</creator><creatorcontrib>Varbo, Anette ; Nordestgaard, Børge G. ; Tybjærg-Hansen, Anne ; Schnohr, Peter ; Jensen, Gorm B. ; Benn, Marianne</creatorcontrib><description>Objective:
Current guidelines on stroke prevention have recommendations on desirable cholesterol levels, but not on nonfasting triglycerides. We compared stepwise increasing levels of nonfasting triglycerides and cholesterol for their association with risk of ischemic stroke in the general population.
Methods:
A total of 7,579 women and 6,372 men from the Copenhagen City Heart Study with measurements of nonfasting triglycerides and cholesterol at baseline in 1976–1978 were followed for up to 33 years; of these, 837 women and 837 men developed ischemic stroke during follow‐up, which was 100% complete.
Results:
The fluctuation of nonfasting triglycerides and cholesterol over 15 years was similar. In both women and men, stepwise increasing levels of nonfasting triglycerides were associated with increased risk of ischemic stroke. Compared to women with triglycerides <1 mmol/liter, multivariate adjusted hazard ratios ranged from 1.2 (95% confidence interval [CI], 0.9–1.7) for triglyceride levels of 1.00–1.99 mmol/liter to 3.9 (95%CI, 1.3–11.1) for triglyceride levels ≥5 mmol/liter (trend: p < 0.001); corresponding hazard ratios in men ranged from 1.2 (95%CI, 0.8–1.7) to 2.3 (95%CI, 1.2–4.3) (p = 0.001). Increasing cholesterol levels were not associated with risk of ischemic stroke except in men with cholesterol levels ≥9.00 mmol/liter vs <5.00 mmol/liter, with a hazard ratio of 4.4 (95%CI, 1.9–10.6).
Interpretation:
In women, stepwise increasing levels of nonfasting triglycerides were associated with increasing risk of ischemic stroke while increasing cholesterol levels were not. In men, these results were similar except that cholesterol ≥9.00 mmol/liter was associated with increased risk of ischemic stroke. ANN NEUROL, 2011</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.22384</identifier><identifier>PMID: 21337605</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers - blood ; Brain Ischemia - blood ; Brain Ischemia - complications ; Cerebral Infarction - complications ; Cholesterol ; Cholesterol, LDL - blood ; Confidence intervals ; Confounding Factors (Epidemiology) ; Cross-Sectional Studies ; Denmark - epidemiology ; Drug therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neurology ; Odds Ratio ; Prospective Studies ; Registries ; Risk Assessment ; Risk Factors ; Stroke ; Stroke - blood ; Stroke - epidemiology ; Stroke - etiology ; Triglycerides ; Triglycerides - blood ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Annals of neurology, 2011-04, Vol.69 (4), p.628-634</ispartof><rights>Copyright © 2011 American Neurological Association</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Neurological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4524-545dc56a51cae424829a38631cae785b7df8f4c26885f65bf0fed459f86a231f3</citedby><cites>FETCH-LOGICAL-c4524-545dc56a51cae424829a38631cae785b7df8f4c26885f65bf0fed459f86a231f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24147760$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21337605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Varbo, Anette</creatorcontrib><creatorcontrib>Nordestgaard, Børge G.</creatorcontrib><creatorcontrib>Tybjærg-Hansen, Anne</creatorcontrib><creatorcontrib>Schnohr, Peter</creatorcontrib><creatorcontrib>Jensen, Gorm B.</creatorcontrib><creatorcontrib>Benn, Marianne</creatorcontrib><title>Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Objective:
Current guidelines on stroke prevention have recommendations on desirable cholesterol levels, but not on nonfasting triglycerides. We compared stepwise increasing levels of nonfasting triglycerides and cholesterol for their association with risk of ischemic stroke in the general population.
Methods:
A total of 7,579 women and 6,372 men from the Copenhagen City Heart Study with measurements of nonfasting triglycerides and cholesterol at baseline in 1976–1978 were followed for up to 33 years; of these, 837 women and 837 men developed ischemic stroke during follow‐up, which was 100% complete.
Results:
The fluctuation of nonfasting triglycerides and cholesterol over 15 years was similar. In both women and men, stepwise increasing levels of nonfasting triglycerides were associated with increased risk of ischemic stroke. Compared to women with triglycerides <1 mmol/liter, multivariate adjusted hazard ratios ranged from 1.2 (95% confidence interval [CI], 0.9–1.7) for triglyceride levels of 1.00–1.99 mmol/liter to 3.9 (95%CI, 1.3–11.1) for triglyceride levels ≥5 mmol/liter (trend: p < 0.001); corresponding hazard ratios in men ranged from 1.2 (95%CI, 0.8–1.7) to 2.3 (95%CI, 1.2–4.3) (p = 0.001). Increasing cholesterol levels were not associated with risk of ischemic stroke except in men with cholesterol levels ≥9.00 mmol/liter vs <5.00 mmol/liter, with a hazard ratio of 4.4 (95%CI, 1.9–10.6).
Interpretation:
In women, stepwise increasing levels of nonfasting triglycerides were associated with increasing risk of ischemic stroke while increasing cholesterol levels were not. In men, these results were similar except that cholesterol ≥9.00 mmol/liter was associated with increased risk of ischemic stroke. ANN NEUROL, 2011</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - complications</subject><subject>Cerebral Infarction - complications</subject><subject>Cholesterol</subject><subject>Cholesterol, LDL - blood</subject><subject>Confidence intervals</subject><subject>Confounding Factors (Epidemiology)</subject><subject>Cross-Sectional Studies</subject><subject>Denmark - epidemiology</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Stroke - blood</subject><subject>Stroke - epidemiology</subject><subject>Stroke - etiology</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqF0d9rUzEUB_AgiqvTB_8BCYiIsLvl9819LNN1yqgvk4EvIc1N2mxp0iX3ov3vTW03QRCfQuBzTk7OF4DXGJ1ihMiZjvqUECrZEzDBnOJGEtY9BRNEBWs4puwIvCjlFiHUCYyegyOCKW0F4hNwPU_R6TL4uIRD9suwNTb73pYTaFYp2DLYnMIJ1LGHvpiVXXsDy5DTnYU-wmFl4dJGm3WAm7QZgx58ii_BM6dDsa8O5zH4dvHp-vyyufo6-3w-vWoM46ROxnhvuNAcG20ZYZJ0mkpBd9dW8kXbO-mYIUJK7gRfOORsz3jnpNCEYkePwft9301O92OdVa3rjDYEHW0ai5JSoq5Dov2_FHUfQhJa5du_5G0ac6zfUJhjwQSWdNfvw16ZnErJ1qlN9mudtwojtctE1UzU70yqfXPoOC7Wtn-UDyFU8O4AdDE6uKyj8eWPY5i1FVZ3tnc_fLDbf7-opvPpw9PNvsLXHH8-Vuh8p-pSWq5u5jP15fvNRzy7lOqC_gJKuLCg</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Varbo, Anette</creator><creator>Nordestgaard, Børge G.</creator><creator>Tybjærg-Hansen, Anne</creator><creator>Schnohr, Peter</creator><creator>Jensen, Gorm B.</creator><creator>Benn, Marianne</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population</title><author>Varbo, Anette ; Nordestgaard, Børge G. ; Tybjærg-Hansen, Anne ; Schnohr, Peter ; Jensen, Gorm B. ; Benn, Marianne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4524-545dc56a51cae424829a38631cae785b7df8f4c26885f65bf0fed459f86a231f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - complications</topic><topic>Cerebral Infarction - complications</topic><topic>Cholesterol</topic><topic>Cholesterol, LDL - blood</topic><topic>Confidence intervals</topic><topic>Confounding Factors (Epidemiology)</topic><topic>Cross-Sectional Studies</topic><topic>Denmark - epidemiology</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Stroke - blood</topic><topic>Stroke - epidemiology</topic><topic>Stroke - etiology</topic><topic>Triglycerides</topic><topic>Triglycerides - blood</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Varbo, Anette</creatorcontrib><creatorcontrib>Nordestgaard, Børge G.</creatorcontrib><creatorcontrib>Tybjærg-Hansen, Anne</creatorcontrib><creatorcontrib>Schnohr, Peter</creatorcontrib><creatorcontrib>Jensen, Gorm B.</creatorcontrib><creatorcontrib>Benn, Marianne</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Varbo, Anette</au><au>Nordestgaard, Børge G.</au><au>Tybjærg-Hansen, Anne</au><au>Schnohr, Peter</au><au>Jensen, Gorm B.</au><au>Benn, Marianne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2011-04</date><risdate>2011</risdate><volume>69</volume><issue>4</issue><spage>628</spage><epage>634</epage><pages>628-634</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>Objective:
Current guidelines on stroke prevention have recommendations on desirable cholesterol levels, but not on nonfasting triglycerides. We compared stepwise increasing levels of nonfasting triglycerides and cholesterol for their association with risk of ischemic stroke in the general population.
Methods:
A total of 7,579 women and 6,372 men from the Copenhagen City Heart Study with measurements of nonfasting triglycerides and cholesterol at baseline in 1976–1978 were followed for up to 33 years; of these, 837 women and 837 men developed ischemic stroke during follow‐up, which was 100% complete.
Results:
The fluctuation of nonfasting triglycerides and cholesterol over 15 years was similar. In both women and men, stepwise increasing levels of nonfasting triglycerides were associated with increased risk of ischemic stroke. Compared to women with triglycerides <1 mmol/liter, multivariate adjusted hazard ratios ranged from 1.2 (95% confidence interval [CI], 0.9–1.7) for triglyceride levels of 1.00–1.99 mmol/liter to 3.9 (95%CI, 1.3–11.1) for triglyceride levels ≥5 mmol/liter (trend: p < 0.001); corresponding hazard ratios in men ranged from 1.2 (95%CI, 0.8–1.7) to 2.3 (95%CI, 1.2–4.3) (p = 0.001). Increasing cholesterol levels were not associated with risk of ischemic stroke except in men with cholesterol levels ≥9.00 mmol/liter vs <5.00 mmol/liter, with a hazard ratio of 4.4 (95%CI, 1.9–10.6).
Interpretation:
In women, stepwise increasing levels of nonfasting triglycerides were associated with increasing risk of ischemic stroke while increasing cholesterol levels were not. In men, these results were similar except that cholesterol ≥9.00 mmol/liter was associated with increased risk of ischemic stroke. ANN NEUROL, 2011</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21337605</pmid><doi>10.1002/ana.22384</doi><tpages>7</tpages></addata></record> |
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| ispartof | Annals of neurology, 2011-04, Vol.69 (4), p.628-634 |
| issn | 0364-5134 1531-8249 |
| language | eng |
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| source | Wiley |
| subjects | Aged Aged, 80 and over Biological and medical sciences Biomarkers - blood Brain Ischemia - blood Brain Ischemia - complications Cerebral Infarction - complications Cholesterol Cholesterol, LDL - blood Confidence intervals Confounding Factors (Epidemiology) Cross-Sectional Studies Denmark - epidemiology Drug therapy Female Follow-Up Studies Humans Male Medical sciences Middle Aged Multivariate Analysis Neurology Odds Ratio Prospective Studies Registries Risk Assessment Risk Factors Stroke Stroke - blood Stroke - epidemiology Stroke - etiology Triglycerides Triglycerides - blood Vascular diseases and vascular malformations of the nervous system |
| title | Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population |
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