Intracellular signal transduction as a factor in the development of "Smart" biomaterials for bone tissue engineering

Signal transduction involves studying the intracellular mechanisms that govern cellular responses to external stimuli such as hormones, cytokines, and also cell adhesion to biomaterials surfaces. Several events have been shown to be responsible for cellular adhesion and adaptation onto different sur...

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Bibliographic Details
Published in:Biotechnology and bioengineering 2011-06, Vol.108 (6), p.1246-1250
Main Authors: Zambuzzi, Willian F., Coelho, Paulo G., Alves, Gutemberg G., Granjeiro, José M.
Format: Article
Language:English
Subjects:
Adhesion
Animals
Biocompatible Materials - metabolism
Bioengineering
Biological and medical sciences
Biomedical materials
Biotechnology
Cell Adhesion
Cell adhesion & migration
Cellular
Cytokines
Cytoskeleton
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Hormones
Humans
Implant
Industrial applications and implications. Economical aspects
Kinases
Material Development
Miscellaneous
Osteoblasts - cytology
Osteoblasts - metabolism
Phosphorylation
Prostheses and Implants
Signal Transduction
Surgical implants
Tissue Engineering - methods
Tyrosine
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Summary:Signal transduction involves studying the intracellular mechanisms that govern cellular responses to external stimuli such as hormones, cytokines, and also cell adhesion to biomaterials surfaces. Several events have been shown to be responsible for cellular adhesion and adaptation onto different surfaces. For instance, cytoskeletal rearrangements during cell adhesion require the recruitment of specific protein tyrosine kinases into focal adhesion structures that promote transient focal adhesion kinase and Src phosphorylations, initially modulating cell behavior. In addition, the phosphorylation of tyrosine (Y) residues have been generally accepted as a critical regulator of a wide range of cell‐related processes, including cell proliferation, migration, differentiation, survival signalling, and energy metabolism. The understanding of the signaling involved on the mechanisms of osteoblast adhesion, proliferation, and differentiation on implant surfaces is fundamental for the successful design of novel “smart” materials, potentially decreasing the repair time, thereby allowing for faster patient rehabilitation. Biotechnol. Bioeng. © 2011 Wiley Periodicals, Inc.
ISSN:0006-3592
1097-0290
1097-0290
DOI:10.1002/bit.23117